%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Srinivasan Pugazhendhi, Kirankumar Baskaran, Srikanth Santhanam, Balakrishnan S. Ramakrishna
Association of ATG16L1 gene haplotype with inflammatory bowel disease in Indians
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 11 0 R/Contents 12 0 R/TrimBox[0 0 612 792]>>
endobj
11 0 obj
[13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R]
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref003)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref006)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref007)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref008)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref006)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref009)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref010)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref011)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref016)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref017)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref018)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref019)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref021)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref022)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref023)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref006)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref017)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref024)>>
endobj
31 0 obj
<>/Border[0 0 0]/A 32 0 R>>
endobj
32 0 obj
<>
endobj
12 0 obj
[33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R]
endobj
33 0 obj
<>stream
q
0.83 0.64 0.02 0 k
349.5118 693.2976 m
354.274 693.2976 l
h
f*
358.3559 667.3323 m
363.1181 667.3323 l
h
f*
298.715 602.3055 m
303.4772 602.3055 l
h
f*
305.6882 602.3055 m
310.4504 602.3055 l
h
f*
546.1228 576.3402 m
550.885 576.3402 l
h
f*
267.7039 459.326 m
272.4661 459.326 l
h
f*
274.7339 459.326 m
284.2583 459.326 l
h
f*
364.3087 446.3433 m
373.8331 446.3433 l
h
f*
378.9921 446.3433 m
388.5165 446.3433 l
h
f*
396.9071 420.3213 m
406.4315 420.3213 l
h
f*
458.4189 407.3386 m
467.9433 407.3386 l
h
f*
291.5717 381.3165 m
301.0961 381.3165 l
h
f*
306.2551 381.3165 m
315.7795 381.3165 l
h
f*
516.9827 244.6299 m
526.1669 244.6299 l
h
f*
528.2646 244.6299 m
537.4488 244.6299 l
h
f*
458.4756 81.9213 m
463.2378 81.9213 l
h
f*
465.5055 81.9213 m
475.0299 81.9213 l
h
f*
517.6063 81.9213 m
527.1307 81.9213 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(studies)Tj
2.9876 0 Td
(\(GWAS\))Tj
3.7361 0 Td
(provided)Tj
3.8211 0 Td
(further)Tj
3.0273 0 Td
(insights)Tj
3.3166 0 Td
(into)Tj
1.8368 0 Td
(the)Tj
1.474 0 Td
(genetic)Tj
3.0671 0 Td
(architecture)Tj
5.0116 0 Td
(of)Tj
1.0148 0 Td
(IBD,)Tj
2.0976 0 Td
(unravelling)Tj
4.7565 0 Td
(163)Tj
-36.1471 -1.3039 Td
(susceptibility)Tj
5.4368 0 Td
(loci)Tj
1.6667 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4684 0 Td
(end)Tj
1.7234 0 Td
(of)Tj
1.0148 0 Td
(2012)Tj
2.1203 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(].)Tj
1.6044 0 Td
(Disturbances)Tj
5.4765 0 Td
(in)Tj
1.0375 0 Td
(autophagy)Tj
4.3823 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(implicated)Tj
4.4447 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
-36.7537 -1.2982 Td
(potential)Tj
3.7587 0 Td
(pathogenetic)Tj
5.3517 0 Td
(pathway)Tj
3.5717 0 Td
(in)Tj
1.0374 0 Td
(IBD)Tj
1.8766 0 Td
(following)Tj
3.9798 0 Td
(the)Tj
1.4683 0 Td
(discovery)Tj
4.0082 0 Td
(that)Tj
1.7801 0 Td
(SNPs)Tj
2.3528 0 Td
(of)Tj
1.0148 0 Td
(genes)Tj
2.4434 0 Td
(involved)Tj
3.6454 0 Td
(in)Tj
-36.2889 -1.2983 Td
(this)Tj
1.6724 0 Td
(pathway)Tj
3.5716 0 Td
(were)Tj
2.1203 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(IBD)Tj
1.8765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
-14.2978 -1.2983 Td
(Autophagy)Tj
4.6374 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.652 0 Td
(cellular)Tj
3.1407 0 Td
(process)Tj
3.1805 0 Td
(that)Tj
1.7801 0 Td
(involves)Tj
3.481 0 Td
(the)Tj
1.474 0 Td
(sequestration)Tj
5.5445 0 Td
(and)Tj
1.7348 0 Td
(eventual)Tj
3.5716 0 Td
(destruction)Tj
4.7792 0 Td
(of)Tj
-36.0224 -1.3039 Td
(aging)Tj
2.398 0 Td
(proteins,)Tj
3.7418 0 Td
(damaged)Tj
3.8494 0 Td
(cell)Tj
1.559 0 Td
(organelles,)Tj
4.4731 0 Td
(apoptotic)Tj
3.9911 0 Td
(bodies)Tj
2.812 0 Td
(and)Tj
1.7291 0 Td
(intracellular)Tj
5.057 0 Td
(bacterial)Tj
3.6283 0 Td
(compo-)Tj
-33.2388 -1.2982 Td
(nents)Tj
2.398 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.652 0 Td
(specialized)Tj
4.524 0 Td
(double)Tj
2.9594 0 Td
(membrane)Tj
4.5638 0 Td
(vesicle)Tj
2.8232 0 Td
(called)Tj
2.5172 0 Td
(the)Tj
1.474 0 Td
(autophagosome.)Tj
6.7748 0 Td
(Autophagy)Tj
4.6317 0 Td
(plays)Tj
2.2337 0 Td
(a)Tj
-36.7367 -1.2983 Td
(pivotal)Tj
2.9423 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0375 0 Td
(maintenance)Tj
5.3858 0 Td
(of)Tj
1.0148 0 Td
(immune)Tj
3.6283 0 Td
(homeostasis)Tj
5.0853 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(gut,)Tj
1.7405 0 Td
(contributing)Tj
5.244 0 Td
(to)Tj
1.0262 0 Td
(both)Tj
2.0636 0 Td
(innate)Tj
-33.4429 -1.3039 Td
(and)Tj
1.7291 0 Td
(adaptive)Tj
3.5773 0 Td
(immunity)Tj
4.2236 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
-8.3338 -1.2983 Td
(The)Tj
1.7858 0 Td
(link)Tj
1.7801 0 Td
(between)Tj
3.5263 0 Td
(autophagy)Tj
4.388 0 Td
(and)Tj
1.7291 0 Td
(CD)Tj
1.6158 0 Td
(pathogenesis)Tj
5.3574 0 Td
(became)Tj
3.2485 0 Td
(first)Tj
1.8085 0 Td
(apparent)Tj
3.7644 0 Td
(when)Tj
2.4037 0 Td
(an)Tj
1.2019 0 Td
(as-)Tj
-33.8057 -1.2983 Td
(sociation)Tj
3.8324 0 Td
(was)Tj
1.7007 0 Td
(identified)Tj
4.0592 0 Td
(between)Tj
3.5263 0 Td
(autophagy)Tj
4.388 0 Td
(related)Tj
2.9424 0 Td
(16-like)Tj
2.9536 0 Td
(1)Tj
0.6974 0 Td
(gene)Tj
2.0806 0 Td
(\()Tj
/F9 1 Tf
[()89()-5( \n)]TJ
/F8 1 Tf
(\))Tj
4.7395 0 Td
(and)Tj
1.7291 0 Td
(CD)Tj
1.6214 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
/F9 1 Tf
-34.2706 -1.3039 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0591 0 Td
(encodes)Tj
3.4356 0 Td
(a)Tj
0.652 0 Td
(small)Tj
2.33 0 Td
(coiled)Tj
2.6136 0 Td
(coil)Tj
1.6611 0 Td
(protein)Tj
3.1521 0 Td
(which)Tj
2.6532 0 Td
(interacts)Tj
3.6453 0 Td
(with)Tj
1.9956 0 Td
(ATG5)Tj
2.7099 0 Td
(and)Tj
1.7291 0 Td
(ATG12)Tj
3.1805 0 Td
(to)Tj
1.0261 0 Td
(form)Tj
2.2053 0 Td
(a)Tj
-37.0485 -1.2982 Td
(350)Tj
1.644 0 Td
(kDa)Tj
1.8879 0 Td
(multimeric)Tj
4.6828 0 Td
(complex)Tj
3.6227 0 Td
(that)Tj
1.7801 0 Td
(plays)Tj
2.2337 0 Td
(a)Tj
0.652 0 Td
(crucial)Tj
2.914 0 Td
(role)Tj
1.7688 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(bulk)Tj
1.9955 0 Td
(degradation)Tj
5.023 0 Td
(or)Tj
1.0998 0 Td
(autophagy)Tj
4.388 0 Td
(of)Tj
-36.1981 -1.2983 Td
(cytoplasmic)Tj
4.9719 0 Td
(proteins)Tj
3.5149 0 Td
(and)Tj
1.7291 0 Td
(organelles.)Tj
4.4731 0 Td
(ATG16L1)Tj
4.1952 0 Td
(protein)Tj
3.1521 0 Td
(is)Tj
0.8504 0 Td
(expressed)Tj
4.0932 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(colon,)Tj
2.6759 0 Td
(small)Tj
2.3244 0 Td
(bowel,)Tj
-34.486 -1.3039 Td
(intestinal)Tj
3.9117 0 Td
(epithelial)Tj
3.8721 0 Td
(cells,)Tj
2.143 0 Td
(leukocytes)Tj
4.3824 0 Td
(and)Tj
1.7291 0 Td
(spleen.)Tj
2.965 0 Td
(A)Tj
0.9071 0 Td
(coding)Tj
2.9593 0 Td
(SNP,)Tj
2.2167 0 Td
(named)Tj
2.9707 0 Td
(rs2241880,)Tj
4.5071 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
/F9 1 Tf
-33.6016 -1.2983 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0591 0 Td
(was)Tj
1.7008 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0205 0 Td
(have)Tj
2.0636 0 Td
(a)Tj
0.6519 0 Td
(disease)Tj
3.0161 0 Td
(association)Tj
4.6318 0 Td
(with)Tj
1.9956 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(this)Tj
1.6724 0 Td
(was)Tj
1.7008 0 Td
(responsible)Tj
4.7508 0 Td
(for)Tj
1.389 0 Td
(threo-)Tj
-34.6221 -1.2982 Td
(nine)Tj
2.0069 0 Td
(to)Tj
1.0261 0 Td
(alanine)Tj
3.1181 0 Td
(substitution)Tj
4.9889 0 Td
(\(T300A\))Tj
3.6227 0 Td
(at)Tj
0.9524 0 Td
(amino)Tj
2.8006 0 Td
(acid)Tj
1.8709 0 Td
(300)Tj
1.6441 0 Td
(of)Tj
1.0148 0 Td
(protein.)Tj
3.3789 0 Td
(This)Tj
1.9899 0 Td
(SNP)Tj
1.9899 0 Td
(appeared)Tj
3.8664 0 Td
(to)Tj
-34.2706 -1.2983 Td
(account)Tj
3.3788 0 Td
(for)Tj
1.389 0 Td
(all)Tj
1.1452 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(disease)Tj
3.0217 0 Td
(risk)Tj
1.7121 0 Td
(exerted)Tj
3.1522 0 Td
(by)Tj
1.1848 0 Td
(the)Tj
/F9 1 Tf
1.4684 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(locus.)Tj
2.5114 0 Td
(Further)Tj
3.2712 0 Td
(replication)Tj
4.5241 0 Td
(studies)Tj
2.982 0 Td
(in)Tj
-36.2832 -1.3039 Td
(an)Tj
1.2018 0 Td
(independent)Tj
5.2724 0 Td
(UK)Tj
1.6328 0 Td
(cohort)Tj
2.8516 0 Td
(confirmed)Tj
4.3994 0 Td
(the)Tj
1.4683 0 Td
(association)Tj
4.6261 0 Td
(existing)Tj
3.3165 0 Td
(between)Tj
3.532 0 Td
(autophagy)Tj
4.3823 0 Td
(and)Tj
1.7348 0 Td
(IBD,)Tj
-34.418 -1.2983 Td
(particularly)Tj
4.8131 0 Td
(CD)Tj
1.6158 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(].)Tj
2.7779 0 Td
(However,)Tj
4.0762 0 Td
(the)Tj
1.474 0 Td
(literature)Tj
3.8778 0 Td
(shows)Tj
2.6645 0 Td
(both)Tj
2.058 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(and)Tj
1.7292 0 Td
(lack)Tj
1.8198 0 Td
(of)Tj
1.0148 0 Td
(association)Tj
-32.6492 -1.2983 Td
(of)Tj
1.0147 0 Td
(IBD)Tj
1.8766 0 Td
(with)Tj
1.9955 0 Td
(SNPs)Tj
2.3528 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
/F9 1 Tf
1.4683 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(locus)Tj
2.2847 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
3.5433 0 Td
(All)Tj
1.4003 0 Td
(of)Tj
1.0148 0 Td
(9)Tj
/F9 1 Tf
0.6916 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0649 0 Td
(SNPs)Tj
2.3527 0 Td
(that)Tj
1.7745 0 Td
(were)Tj
2.126 0 Td
(genotyped)Tj
-33.0574 -1.3039 Td
(in)Tj
1.0318 0 Td
(a)Tj
0.6576 0 Td
(German)Tj
3.5319 0 Td
(population)Tj
4.5921 0 Td
(displayed)Tj
3.9798 0 Td
(significant)Tj
4.3881 0 Td
(protective)Tj
4.2009 0 Td
(association)Tj
4.6318 0 Td
(with)Tj
1.9955 0 Td
(CD,)Tj
1.8425 0 Td
(the)Tj
1.474 0 Td
(strongest)Tj
-32.326 -1.2982 Td
(association)Tj
4.6261 0 Td
(being)Tj
2.4321 0 Td
(with)Tj
1.9956 0 Td
(rs2241879)Tj
4.2859 0 Td
(and)Tj
1.7291 0 Td
(rs2241880)Tj
4.2803 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
2.075 0 Td
(Other)Tj
/F9 1 Tf
2.5908 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(gene)Tj
2.0806 0 Td
(variants)Tj
3.3902 0 Td
(indepen-)Tj
-33.5449 -1.2983 Td
(dent)Tj
2.0182 0 Td
(of)Tj
1.0148 0 Td
(rs2241880)Tj
4.2803 0 Td
(also)Tj
1.7688 0 Td
(appear)Tj
2.914 0 Td
(to)Tj
1.0261 0 Td
(contribute)Tj
4.3937 0 Td
(to)Tj
1.0261 0 Td
(CD)Tj
1.6214 0 Td
(susceptibility)Tj
5.4369 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.0749 0 Td
(Studies)Tj
3.1011 0 Td
(in)Tj
1.0375 0 Td
(several)Tj
2.9366 0 Td
(Asian)Tj
-34.6504 -1.3039 Td
(countries)Tj
3.9458 0 Td
(including)Tj
4.0421 0 Td
(Japan,)Tj
2.7099 0 Td
(Korea)Tj
2.6306 0 Td
(and)Tj
1.7291 0 Td
(China)Tj
2.6589 0 Td
(failed)Tj
2.4094 0 Td
(to)Tj
1.0261 0 Td
(show)Tj
2.2961 0 Td
(an)Tj
1.2019 0 Td
(association)Tj
4.6318 0 Td
(between)Tj
/F9 1 Tf
3.5262 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
-32.8079 -1.2983 Td
(gene)Tj
2.0806 0 Td
(variants)Tj
3.3902 0 Td
(and)Tj
1.7291 0 Td
(CD)Tj
1.6157 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
-7.6194 -1.2983 Td
(In)Tj
1.1111 0 Td
(light)Tj
2.024 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(conflicting)Tj
4.5071 0 Td
(findings)Tj
3.4922 0 Td
(and)Tj
1.7291 0 Td
(ethnic)Tj
2.7099 0 Td
(differences)Tj
4.5638 0 Td
(in)Tj
1.0375 0 Td
(aforementioned)Tj
6.6046 0 Td
(studies)Tj
2.9877 0 Td
(we)Tj
-34.4463 -1.2982 Td
(therefore)Tj
3.855 0 Td
(aimed)Tj
2.6873 0 Td
(at)Tj
0.9524 0 Td
(analyzing)Tj
4.0365 0 Td
(various)Tj
3.1408 0 Td
(polymorphisms)Tj
6.497 0 Td
(in)Tj
/F9 1 Tf
1.0374 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(gene)Tj
2.0806 0 Td
(for)Tj
1.3833 0 Td
(its)Tj
1.1452 0 Td
(association)Tj
4.6318 0 Td
(with)Tj
-35.5065 -1.3039 Td
(CD)Tj
1.6157 0 Td
(and)Tj
1.7348 0 Td
(UC)Tj
1.6157 0 Td
(in)Tj
1.0375 0 Td
(Indian)Tj
2.8856 0 Td
(population.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 314.7023 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 297.6944 cm
BT
/F8 1 Tf
1 TL
-0.02 Tc
0 0 Td
(876)Tj
1.5987 0 Td
(participants)Tj
4.7622 0 Td
(were)Tj
2.0636 0 Td
(recruited)Tj
3.7077 0 Td
(from)Tj
2.1429 0 Td
(patients)Tj
3.2372 0 Td
(attending)Tj
3.8891 0 Td
(the)Tj
1.423 0 Td
(outpatient)Tj
4.1782 0 Td
(and)Tj
1.6838 0 Td
(inpatient)Tj
3.6793 0 Td
(services)Tj
3.1748 0 Td
(of)Tj
-35.5405 -1.2982 Td
(the)Tj
1.4229 0 Td
(Department)Tj
4.9266 0 Td
(of)Tj
0.9865 0 Td
(Gastrointestinal)Tj
6.3439 0 Td
(Sciences)Tj
3.4355 0 Td
(at)Tj
0.9241 0 Td
(the)Tj
1.4173 0 Td
(Christian)Tj
3.8154 0 Td
(Medical)Tj
3.3222 0 Td
(College.)Tj
3.2939 0 Td
(The)Tj
1.7348 0 Td
(cohort)Tj
2.7609 0 Td
(com-)Tj
-34.384 -1.3039 Td
(prised)Tj
2.5908 0 Td
(of)Tj
0.9808 0 Td
(234)Tj
1.5987 0 Td
(CD)Tj
1.5874 0 Td
(patients,)Tj
3.4526 0 Td
(249)Tj
1.5987 0 Td
(UC)Tj
1.5874 0 Td
(patients)Tj
3.2371 0 Td
(and)Tj
1.6838 0 Td
(393)Tj
1.5987 0 Td
(healthy)Tj
3.0218 0 Td
(controls)Tj
3.3562 0 Td
(\(HC\).)Tj
2.4774 0 Td
(The)Tj
1.7348 0 Td
(diagnosis)Tj
3.8098 0 Td
(of)Tj
0.9864 0 Td
(CD)Tj
-35.3024 -1.2983 Td
(and)Tj
1.678 0 Td
(UC)Tj
1.5874 0 Td
(was)Tj
1.6441 0 Td
(based)Tj
2.3925 0 Td
(on)Tj
1.2415 0 Td
(a)Tj
0.635 0 Td
(composite)Tj
4.2009 0 Td
(of)Tj
0.9808 0 Td
(clinical,)Tj
3.1521 0 Td
(radiological,)Tj
4.9322 0 Td
(endoscopic,)Tj
4.7735 0 Td
(and)Tj
1.6781 0 Td
(histopathological)Tj
6.7805 0 Td
(find-)Tj
-35.6766 -1.2983 Td
(ings)Tj
1.7971 0 Td
(according)Tj
4.0422 0 Td
(to)Tj
0.9921 0 Td
(the)Tj
1.423 0 Td
(consensus)Tj
4.1385 0 Td
(criteria)Tj
2.9481 0 Td
(of)Tj
0.9807 0 Td
(the)Tj
1.423 0 Td
(Indian)Tj
2.7893 0 Td
(Society)Tj
2.9593 0 Td
(of)Tj
0.9808 0 Td
(Gastroenterology)Tj
6.8995 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
3.1238 0 Td
(Patients)Tj
-34.4974 -1.2982 Td
(with)Tj
1.9332 0 Td
(proven)Tj
2.948 0 Td
(intestinal)Tj
3.753 0 Td
(or)Tj
1.0658 0 Td
(extra-intestinal)Tj
5.9981 0 Td
(tuberculosis)Tj
4.8472 0 Td
(were)Tj
2.058 0 Td
(excluded.)Tj
3.8664 0 Td
(Participants)Tj
4.8075 0 Td
(who)Tj
1.8936 0 Td
(refused)Tj
3.033 0 Td
(the)Tj
-36.2038 -1.3039 Td
(consent)Tj
3.2144 0 Td
(to)Tj
0.9978 0 Td
(participate)Tj
4.2916 0 Td
(were)Tj
2.0636 0 Td
(also)Tj
1.7008 0 Td
(excluded.)Tj
3.8665 0 Td
(Healthy)Tj
3.2598 0 Td
(adults)Tj
2.5228 0 Td
(accompanying)Tj
5.8677 0 Td
(non-IBD)Tj
3.719 0 Td
(patients)Tj
3.2428 0 Td
(to)Tj
0.9921 0 Td
(the)Tj
-35.7389 -1.2983 Td
(Gastroenterology)Tj
6.8938 0 Td
(clinic)Tj
2.3017 0 Td
(were)Tj
2.0579 0 Td
(recruited)Tj
3.7134 0 Td
(as)Tj
0.9808 0 Td
(controls.)Tj
3.5659 0 Td
(The)Tj
1.7348 0 Td
(history)Tj
2.8913 0 Td
(and)Tj
1.6838 0 Td
(clinical)Tj
2.948 0 Td
(details)Tj
2.6646 0 Td
(were)Tj
2.0579 0 Td
(recorded)Tj
-33.4939 -1.2983 Td
(and)Tj
1.6837 0 Td
(samples)Tj
3.2655 0 Td
(of)Tj
0.9865 0 Td
(venous)Tj
2.948 0 Td
(blood)Tj
2.4321 0 Td
(were)Tj
2.0579 0 Td
(obtained)Tj
3.6057 0 Td
(in)Tj
1.0034 0 Td
(EDTA-coated)Tj
5.6126 0 Td
(Vacutainer)Tj
4.4787 0 Td
(tubes.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 164.9763 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(SNP)Tj
2.2582 0 Td
(genotyping)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 148.0251 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Genomic)Tj
3.9231 0 Td
(DNA)Tj
2.3754 0 Td
(was)Tj
1.7008 0 Td
(isolated)Tj
3.2825 0 Td
(from)Tj
2.2053 0 Td
(8ml)Tj
1.7631 0 Td
(of)Tj
1.0148 0 Td
(EDTAanticoagulated)Tj
9.1729 0 Td
(venous)Tj
3.0444 0 Td
(blood)Tj
2.5115 0 Td
(by)Tj
1.1848 0 Td
(salting)Tj
2.8403 0 Td
(out)Tj
-35.0189 -1.3039 Td
(method.)Tj
3.5489 0 Td
(Isolated)Tj
3.3562 0 Td
(DNA)Tj
2.3754 0 Td
(was)Tj
1.7008 0 Td
(checked)Tj
3.4639 0 Td
(for)Tj
1.389 0 Td
(quality)Tj
2.9537 0 Td
(and)Tj
1.7291 0 Td
(concentration,)Tj
6.0491 0 Td
(and)Tj
1.7291 0 Td
(stored)Tj
2.7099 0 Td
(at)Tj
0.9524 0 Td
(-80C)Tj
2.5739 0 Td
(until)Tj
-34.5314 -1.2982 Td
(analysis.)Tj
3.5489 0 Td
(Ten)Tj
1.8028 0 Td
(SNPsrs2241880,)Tj
7.5628 0 Td
(rs4663396,)Tj
4.5071 0 Td
(rs3792106,)Tj
4.507 0 Td
(rs10210302,)Tj
4.9833 0 Td
(rs3792109,)Tj
4.5071 0 Td
(rs2241877,)Tj
-31.419 -1.2983 Td
(rs6737398,)Tj
4.507 0 Td
(rs11682898,)Tj
4.9833 0 Td
(rs4663402)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(rs4663421)Tj
4.2803 0 Td
(in)Tj
/F9 1 Tf
1.0375 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0591 0 Td
(gene)Tj
2.0807 0 Td
(were)Tj
2.1259 0 Td
(selected)Tj
3.3449 0 Td
(for)Tj
1.389 0 Td
(genotyp-)Tj
-33.8171 -1.3039 Td
(ing.)Tj
1.7234 0 Td
(Our)Tj
1.8652 0 Td
(choice)Tj
2.7949 0 Td
(of)Tj
1.0148 0 Td
(SNPs)Tj
2.3528 0 Td
(for)Tj
1.3833 0 Td
(genotyping)Tj
4.7168 0 Td
(was)Tj
1.7008 0 Td
(based)Tj
2.4718 0 Td
(on)Tj
1.2755 0 Td
(the)Tj
1.4684 0 Td
(following)Tj
3.9798 0 Td
(considerations.)Tj
6.2929 0 Td
(The)Tj
1.7801 0 Td
(first)Tj
-34.8205 -1.2983 Td
(four)Tj
1.9105 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(previously)Tj
4.354 0 Td
(found)Tj
2.6135 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(CD)Tj
1.6157 0 Td
(in)Tj
1.0375 0 Td
(German)Tj
3.5319 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(])Tj
2.5512 0 Td
(and)Tj
1.7348 0 Td
(UK)Tj
1.6271 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(])Tj
1.8538 0 Td
(patients,)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 477.5244 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(ATG16L1)Tj
4.4433 0 Td
(and)Tj
1.8567 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(Indians)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01782)Tj
4.089 0 Td
(91)Tj
0 g
2.0906 0 Td
(May)Tj
2.0906 0 Td
(19,)Tj
1.5803 0 Td
(2017)Tj
35.2349 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
BT
66.402 0 Td
(11)Tj
ET
Q
endstream
endobj
51 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 53 0 R/Contents 54 0 R/TrimBox[0 0 612 792]>>
endobj
53 0 obj
[55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R]
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref025)>>
endobj
56 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref026)>>
endobj
57 0 obj
<>/Border[0 0 0]/A 64 0 R>>
endobj
64 0 obj
<>
endobj
58 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref027)>>
endobj
59 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref028)>>
endobj
60 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t001)>>
endobj
61 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t002)>>
endobj
62 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.s001)>>
endobj
63 0 obj
<>/Border[0 0 0]/A 65 0 R>>
endobj
65 0 obj
<>
endobj
54 0 obj
[66 0 R 67 0 R 68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R 76 0 R 77 0 R]
endobj
66 0 obj
<>stream
q
0.83 0.64 0.02 0 k
524.126 706.337 m
533.6504 706.337 l
h
f*
220.989 537.3354 m
230.5134 537.3354 l
h
f*
200.0126 439.7102 m
334.9417 439.7102 l
h
f*
343.9559 439.7102 m
353.4803 439.7102 l
h
f*
432.737 413.7449 m
442.2614 413.7449 l
h
f*
524.6929 133.9087 m
529.4551 133.9087 l
h
f*
548.2772 133.9087 m
553.0961 133.9087 l
h
f*
263.9622 120.926 m
296.9575 120.926 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(while)Tj
2.3697 0 Td
(the)Tj
1.4683 0 Td
(remaining)Tj
4.3654 0 Td
(six)Tj
1.3096 0 Td
(were)Tj
2.1259 0 Td
(selected)Tj
3.3449 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.474 0 Td
(Hapmap)Tj
3.7077 0 Td
(data)Tj
1.9106 0 Td
(of)Tj
1.0204 0 Td
(Gujarati)Tj
3.5206 0 Td
(Indians)Tj
3.2485 0 Td
([)Tj
0.83 0.64 0.02 0 k
(25)Tj
0 g
(].)Tj
2.075 0 Td
(Of)Tj
1.2586 0 Td
(these)Tj
-35.4045 -1.3039 Td
(SNPs,)Tj
2.5738 0 Td
(rs2241880)Tj
4.2859 0 Td
(is)Tj
0.8448 0 Td
(a)Tj
0.6576 0 Td
(coding)Tj
2.9537 0 Td
(SNP,)Tj
2.2167 0 Td
(rs10210302)Tj
4.7621 0 Td
(is)Tj
0.8448 0 Td
(located)Tj
3.0784 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(5')Tj
0.9127 0 Td
(UTR)Tj
2.1884 0 Td
(region,)Tj
3.0273 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.474 0 Td
(remain-)Tj
-34.0552 -1.2982 Td
(der)Tj
1.542 0 Td
(are)Tj
1.4456 0 Td
(located)Tj
3.0841 0 Td
(in)Tj
1.0318 0 Td
(intronic)Tj
3.4526 0 Td
(regions.)Tj
3.3902 0 Td
(In)Tj
1.1112 0 Td
(German)Tj
3.5319 0 Td
(patients,)Tj
3.5943 0 Td
(rs2241880)Tj
4.2803 0 Td
(and)Tj
1.7292 0 Td
(rs2241879)Tj
4.2802 0 Td
(have)Tj
2.0637 0 Td
(both)Tj
-34.5371 -1.2983 Td
(been)Tj
2.1203 0 Td
(shown)Tj
2.8516 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1508 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(CD,)Tj
1.8425 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(latter)Tj
2.296 0 Td
(being)Tj
2.4322 0 Td
(in)Tj
1.0318 0 Td
(close)Tj
2.1826 0 Td
(LD)Tj
1.4967 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(former.)Tj
3.2258 0 Td
(In)Tj
-34.8375 -1.2983 Td
(other)Tj
2.347 0 Td
(studies,)Tj
3.2088 0 Td
(rs2241880)Tj
4.286 0 Td
(was)Tj
1.6951 0 Td
(the)Tj
1.474 0 Td
(most)Tj
2.2053 0 Td
(replicated)Tj
4.1499 0 Td
(SNP,)Tj
2.2167 0 Td
(and)Tj
1.7291 0 Td
(we)Tj
1.3266 0 Td
(therefore)Tj
3.8551 0 Td
(chose)Tj
2.4662 0 Td
(to)Tj
1.0261 0 Td
(study)Tj
-31.9859 -1.3039 Td
(rs2241880)Tj
4.2802 0 Td
(but)Tj
1.5534 0 Td
(not)Tj
1.5761 0 Td
(rs2241879.)Tj
-6.2135 -1.2982 Td
(Genotyping)Tj
4.9662 0 Td
(of)Tj
/F9 1 Tf
1.0148 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0649 0 Td
(polymorphisms)Tj
6.497 0 Td
(was)Tj
1.6951 0 Td
(performed)Tj
4.473 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.4683 0 Td
(Sequenom-MassArray)Tj
-27.7623 -1.2983 Td
(platform)Tj
3.702 0 Td
(at)Tj
0.9524 0 Td
(NxGenBio)Tj
4.4617 0 Td
(Life)Tj
1.7348 0 Td
(Sciences,)Tj
3.7927 0 Td
(New)Tj
2.0636 0 Td
(Delhi,)Tj
2.6476 0 Td
(India.)Tj
2.5625 0 Td
(As)Tj
1.2642 0 Td
(described)Tj
4.0536 0 Td
(earlier,)Tj
2.982 0 Td
(in)Tj
1.0375 0 Td
(these)Tj
2.2507 0 Td
(assays)Tj
2.6248 0 Td
(a)Tj
-36.1301 -1.3039 Td
(locus)Tj
2.2847 0 Td
(specific)Tj
3.1918 0 Td
(PCR)Tj
2.0636 0 Td
(reaction)Tj
3.4922 0 Td
(was)Tj
1.7008 0 Td
(carried)Tj
3.0387 0 Td
(out)Tj
1.5534 0 Td
(initially,)Tj
3.4696 0 Td
(followed)Tj
3.651 0 Td
(by)Tj
1.1849 0 Td
(a)Tj
0.6519 0 Td
(locus)Tj
2.2847 0 Td
(specific)Tj
3.1918 0 Td
(primer)Tj
2.9877 0 Td
(exten-)Tj
-34.7468 -1.2983 Td
(sion)Tj
1.9048 0 Td
(\(iPLEX\))Tj
3.4866 0 Td
(reaction)Tj
3.4923 0 Td
(in)Tj
1.0318 0 Td
(which)Tj
2.6532 0 Td
(an)Tj
1.2019 0 Td
(oligonucleotide)Tj
6.4062 0 Td
(primer)Tj
2.9877 0 Td
(annealed)Tj
3.8098 0 Td
(immediately)Tj
5.1987 0 Td
(upstream)Tj
3.9741 0 Td
(of)Tj
-36.1471 -1.2983 Td
(the)Tj
1.4683 0 Td
(polymorphic)Tj
5.3801 0 Td
(site)Tj
1.5704 0 Td
(being)Tj
2.4321 0 Td
(genotyped.)Tj
4.6091 0 Td
(SNPs)Tj
2.3528 0 Td
(and)Tj
1.7291 0 Td
(small)Tj
2.3244 0 Td
(insertion/deletion)Tj
7.387 0 Td
(polymorphisms)Tj
-29.2533 -1.3039 Td
(were)Tj
2.1203 0 Td
(detected,)Tj
3.787 0 Td
(by)Tj
1.1792 0 Td
(matrix-assisted)Tj
6.2589 0 Td
(laser)Tj
2.0522 0 Td
(desorption)Tj
4.5468 0 Td
(ionizationtime-of-flight)Tj
10.1876 0 Td
(mass)Tj
2.194 0 Td
(spectrometry)Tj
-32.326 -1.2982 Td
(after)Tj
2.0352 0 Td
(incubating)Tj
4.5071 0 Td
(primer)Tj
2.9877 0 Td
(and)Tj
1.7291 0 Td
(amplified)Tj
4.0138 0 Td
(DNA)Tj
2.3754 0 Td
(with)Tj
1.9956 0 Td
(mass-modified)Tj
6.1738 0 Td
(dideoxynucleotide)Tj
7.5855 0 Td
(termina-)Tj
-33.4032 -1.2983 Td
(tors)Tj
1.7574 0 Td
([)Tj
0.83 0.64 0.02 0 k
(26)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
1.7858 0 Td
(primer)Tj
2.9877 0 Td
(extension)Tj
4.0648 0 Td
(was)Tj
1.6951 0 Td
(made)Tj
2.4265 0 Td
(according)Tj
4.1896 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(sequence)Tj
3.8551 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(variant)Tj
3.0274 0 Td
(site,)Tj
1.7915 0 Td
(and)Tj
-34.6391 -1.3039 Td
(was)Tj
1.6951 0 Td
(a)Tj
0.6576 0 Td
(single)Tj
2.5285 0 Td
(complementary)Tj
6.5083 0 Td
(mass-modified)Tj
6.1738 0 Td
(base.)Tj
2.1713 0 Td
(Genotypes)Tj
4.4674 0 Td
(were)Tj
2.126 0 Td
(assigned)Tj
3.6056 0 Td
(at)Tj
0.9525 0 Td
(each)Tj
2.0295 0 Td
(SNP)Tj
1.99 0 Td
(locus)Tj
-34.9056 -1.2983 Td
(using)Tj
2.3867 0 Td
(SpectroTYPER)Tj
6.2305 0 Td
(software)Tj
3.5887 0 Td
(\(Sequenom\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 483.8173 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Statistical)Tj
4.4504 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 466.8094 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(To)Tj
1.3379 0 Td
(determine)Tj
4.32 0 Td
(association)Tj
4.6317 0 Td
(of)Tj
/F9 1 Tf
1.0148 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(SNPs)Tj
2.3528 0 Td
(with)Tj
1.9956 0 Td
(IBD)Tj
1.8765 0 Td
(susceptibility,)Tj
5.6636 0 Td
(comparison)Tj
4.9776 0 Td
(of)Tj
1.0148 0 Td
(allele)Tj
2.2393 0 Td
(and)Tj
-35.4838 -1.2982 Td
(genotype)Tj
3.855 0 Td
(distributions)Tj
5.3291 0 Td
(among)Tj
2.9934 0 Td
(cases)Tj
2.228 0 Td
(and)Tj
1.7292 0 Td
(controls)Tj
3.4809 0 Td
(was)Tj
1.7008 0 Td
(done)Tj
2.228 0 Td
(using)Tj
2.3867 0 Td
(PLINK)Tj
3.0671 0 Td
(v.)Tj
0.9014 0 Td
(1.07)Tj
1.8709 0 Td
(\(website:)Tj
0.83 0.64 0.02 0 k
-31.7705 -1.3039 Td
(http://zzz.bwh.harvard.edu/pl)Tj
11.8544 0 Td
(ink/)Tj
0 g
(\))Tj
2.1996 0 Td
([)Tj
0.83 0.64 0.02 0 k
(27)Tj
0 g
(].)Tj
2.075 0 Td
(Odds)Tj
2.3867 0 Td
(ratios)Tj
2.4548 0 Td
(\(ORs\),)Tj
2.8573 0 Td
(95%)Tj
1.9276 0 Td
(confidence)Tj
4.6034 0 Td
(intervals)Tj
3.6227 0 Td
(\(CIs\))Tj
-33.9815 -1.2983 Td
(and)Tj
1.7291 0 Td
(P-values)Tj
3.5773 0 Td
(were)Tj
2.1203 0 Td
(calculated.)Tj
4.4333 0 Td
(LD)Tj
1.491 0 Td
(pairwise)Tj
3.549 0 Td
(values,)Tj
2.8913 0 Td
(haplotype)Tj
4.1442 0 Td
(structure,)Tj
4.0479 0 Td
(and)Tj
1.7291 0 Td
(haplotype)Tj
4.1499 0 Td
(frequen-)Tj
-33.8624 -1.2983 Td
(cies)Tj
1.6951 0 Td
(were)Tj
2.1203 0 Td
(determined)Tj
4.8528 0 Td
(using)Tj
2.3868 0 Td
(the)Tj
1.474 0 Td
(Haploview)Tj
4.5184 0 Td
(software)Tj
3.5886 0 Td
(v.)Tj
0.9015 0 Td
(4.2)Tj
1.3946 0 Td
([)Tj
0.83 0.64 0.02 0 k
(28)Tj
0 g
(].)Tj
2.0749 0 Td
(Significance)Tj
5.0513 0 Td
(of)Tj
1.0148 0 Td
(difference)Tj
-31.0731 -1.3039 Td
(between)Tj
3.5262 0 Td
(groups)Tj
2.9707 0 Td
(was)Tj
1.7008 0 Td
(analysed)Tj
3.6453 0 Td
(using)Tj
2.3925 0 Td
(Chi)Tj
1.6781 0 Td
(square)Tj
2.8459 0 Td
(test.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 373.2094 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Ethical)Tj
3.1842 0 Td
(considerations)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 356.2015 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(Institutional)Tj
5.1647 0 Td
(Review)Tj
3.0954 0 Td
(Board)Tj
2.6362 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(Christian)Tj
3.9628 0 Td
(Medical)Tj
3.4356 0 Td
(College)Tj
3.1918 0 Td
(approved)Tj
3.9742 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3924 0 Td
(protocol)Tj
-33.5846 -1.2982 Td
(and)Tj
1.7291 0 Td
(consent)Tj
3.3278 0 Td
(forms.)Tj
2.795 0 Td
(Informed)Tj
4.0478 0 Td
(written)Tj
3.1068 0 Td
(consent)Tj
3.3335 0 Td
(for)Tj
1.3833 0 Td
(genetic)Tj
3.0727 0 Td
(testing)Tj
2.88 0 Td
(was)Tj
1.7008 0 Td
(obtained)Tj
3.7304 0 Td
(from)Tj
2.2053 0 Td
(all)Tj
1.1509 0 Td
(study)Tj
-34.4634 -1.3039 Td
(participants)Tj
4.9549 0 Td
(and)Tj
1.7291 0 Td
(from)Tj
2.211 0 Td
(parents)Tj
3.1691 0 Td
(of)Tj
1.0148 0 Td
(minors)Tj
3.0954 0 Td
(participating)Tj
5.3291 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(study.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 301.6062 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 284.5984 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Of)Tj
1.2529 0 Td
(the)Tj
1.4683 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(152)Tj
1.6498 0 Td
(were)Tj
2.1203 0 Td
(male)Tj
2.143 0 Td
(and)Tj
1.7291 0 Td
(82)Tj
1.1735 0 Td
(female)Tj
2.8517 0 Td
(and)Tj
1.7348 0 Td
(their)Tj
2.1033 0 Td
(ages)Tj
1.9048 0 Td
(ranged)Tj
2.9934 0 Td
(from)Tj
2.2053 0 Td
(1078)Tj
2.6362 0 Td
(years)Tj
-32.9553 -1.2982 Td
(\(median)Tj
3.5773 0 Td
(44\).)Tj
1.7404 0 Td
(Eighty)Tj
2.8006 0 Td
(eight)Tj
2.1997 0 Td
(had)Tj
1.7121 0 Td
(ileocolonic)Tj
4.5864 0 Td
(disease,)Tj
3.2429 0 Td
(78)Tj
1.1735 0 Td
(had)Tj
1.7064 0 Td
(ileal)Tj
1.8369 0 Td
(disease,)Tj
3.2428 0 Td
(56)Tj
1.1735 0 Td
(had)Tj
1.7065 0 Td
(colonic)Tj
3.1464 0 Td
(disease,)Tj
3.2428 0 Td
(7)Tj
-37.0882 -1.3039 Td
(had)Tj
1.7064 0 Td
(upper)Tj
2.5795 0 Td
(GI)Tj
1.2756 0 Td
(involvement)Tj
5.21 0 Td
(alone,)Tj
2.6079 0 Td
(and)Tj
1.7291 0 Td
(5)Tj
0.6973 0 Td
(had)Tj
1.7065 0 Td
(ileocolonic)Tj
4.5864 0 Td
(disease)Tj
3.0161 0 Td
(with)Tj
2.0012 0 Td
(involvement)Tj
5.21 0 Td
(of)Tj
1.0148 0 Td
(upper)Tj
2.5796 0 Td
(GI)Tj
-35.9204 -1.2983 Td
(tract.)Tj
2.2677 0 Td
(Forty)Tj
2.381 0 Td
(three)Tj
2.2621 0 Td
(had)Tj
1.7121 0 Td
(stricturing)Tj
4.422 0 Td
(disease,)Tj
3.2428 0 Td
(22)Tj
1.1679 0 Td
(had)Tj
1.7121 0 Td
(penetrating)Tj
4.8132 0 Td
(disease)Tj
3.016 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(remaining)Tj
4.3653 0 Td
(had)Tj
-34.5654 -1.2983 Td
(non-stricturing)Tj
6.3722 0 Td
(non-penetrating)Tj
6.7691 0 Td
(disease.)Tj
3.2428 0 Td
(Of)Tj
1.2586 0 Td
(the)Tj
1.4683 0 Td
(UC)Tj
1.6214 0 Td
(patients)Tj
3.3676 0 Td
(145)Tj
1.644 0 Td
(were)Tj
2.126 0 Td
(male)Tj
2.143 0 Td
(and)Tj
1.7291 0 Td
(104)Tj
1.6441 0 Td
(female,)Tj
-33.3862 -1.2982 Td
(and)Tj
1.7291 0 Td
(their)Tj
2.1089 0 Td
(ages)Tj
1.9049 0 Td
(ranged)Tj
2.9877 0 Td
(from)Tj
2.2053 0 Td
(15)Tj
1.1736 0 Td
(to)Tj
1.0261 0 Td
(76)Tj
1.1679 0 Td
(years)Tj
2.2677 0 Td
(\(median)Tj
3.5773 0 Td
(39\).)Tj
1.7404 0 Td
(Thirty)Tj
2.7496 0 Td
(four)Tj
1.9106 0 Td
(had)Tj
1.7121 0 Td
(proctitis,)Tj
3.753 0 Td
(63)Tj
1.1736 0 Td
(had)Tj
1.7121 0 Td
(left)Tj
-34.8999 -1.3039 Td
(sided)Tj
2.3243 0 Td
(colitis)Tj
2.5909 0 Td
(and)Tj
1.7291 0 Td
(152)Tj
1.6498 0 Td
(had)Tj
1.7064 0 Td
(extensive)Tj
3.8891 0 Td
(colitis)Tj
2.5909 0 Td
(or)Tj
1.0941 0 Td
(pancolitis.)Tj
4.3143 0 Td
(The)Tj
1.7859 0 Td
(healthy)Tj
3.1294 0 Td
(controls,)Tj
3.7077 0 Td
(256)Tj
1.6497 0 Td
(male)Tj
2.143 0 Td
(and)Tj
1.7291 0 Td
(143)Tj
-36.0337 -1.2983 Td
(female,)Tj
3.0784 0 Td
(ranged)Tj
2.9933 0 Td
(in)Tj
1.0318 0 Td
(age)Tj
1.5421 0 Td
(from)Tj
2.2053 0 Td
(1573)Tj
2.6419 0 Td
(years)Tj
2.262 0 Td
(\(median)Tj
3.583 0 Td
(30\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 164.9763 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(SNP)Tj
2.2582 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 148.0251 cm
BT
/F8 1 Tf
1 TL
-0.02 Tc
0 0 Td
(All)Tj
1.3492 0 Td
(investigated)Tj
4.7962 0 Td
(polymorphisms)Tj
6.2872 0 Td
(were)Tj
2.058 0 Td
(in)Tj
1.0034 0 Td
(Hardy)Tj
2.6986 0 Td
(Weinberg)Tj
4.0648 0 Td
(equilibrium)Tj
4.7736 0 Td
(in)Tj
1.0034 0 Td
(cases)Tj
2.143 0 Td
(and)Tj
1.6838 0 Td
(controls.)Tj
3.5603 0 Td
(The)Tj
-35.4215 -1.3039 Td
(allele)Tj
2.1429 0 Td
(and)Tj
1.6838 0 Td
(genotype)Tj
3.7304 0 Td
(frequencies)Tj
4.6091 0 Td
(of)Tj
/F9 1 Tf
0.9808 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
3.9458 0 Td
(polymorphisms)Tj
6.2928 0 Td
(are)Tj
1.4003 0 Td
(presented)Tj
3.9685 0 Td
(in)Tj
1.0035 0 Td
(Tables)Tj
0.83 0.64 0.02 0 k
2.7099 0 Td
(1)Tj
0 g
0.6803 0 Td
(and)Tj
0.83 0.64 0.02 0 k
1.6781 0 Td
(2)Tj
0 g
-34.8262 -1.2982 Td
(respectively)Tj
4.6941 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7008 0 Td
(S1)Tj
1.1395 0 Td
(Table)Tj
0 g
2.3641 0 Td
(for)Tj
1.3379 0 Td
(individual)Tj
4.1272 0 Td
(level)Tj
1.9332 0 Td
(data\).)Tj
2.3868 0 Td
(Association)Tj
4.6998 0 Td
(analysis)Tj
3.1975 0 Td
(was)Tj
1.6497 0 Td
(carried)Tj
2.931 0 Td
(out)Tj
1.5024 0 Td
(by)Tj
1.1508 0 Td
(com-)Tj
-34.8148 -1.2983 Td
(paring)Tj
2.7269 0 Td
(the)Tj
1.4229 0 Td
(allele)Tj
2.143 0 Td
(and)Tj
1.6838 0 Td
(genotype)Tj
3.7304 0 Td
(frequencies)Tj
4.6034 0 Td
(of)Tj
/F9 1 Tf
0.9864 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
3.9459 0 Td
(markers)Tj
3.3845 0 Td
(amidst)Tj
2.8346 0 Td
(cases)Tj
2.143 0 Td
(and)Tj
1.6838 0 Td
(controls.)Tj
/F13 1 Tf
-0.004 Tc
-30.0924 -1.3039 Td
(rs4663402)Tj
4.4843 0 Td
(and)Tj
1.7915 0 Td
(rs4663421.)Tj
/F8 1 Tf
5.3065 0 Td
(rs4663402)Tj
4.2802 0 Td
(and)Tj
1.7292 0 Td
(rs4663421)Tj
4.2803 0 Td
(exhibited)Tj
3.9287 0 Td
(unequivocal)Tj
5.0854 0 Td
(association)Tj
-32.0823 -1.2983 Td
(with)Tj
1.9955 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7292 0 Td
(UC)Tj
1.6214 0 Td
(in)Tj
1.0318 0 Td
(terms)Tj
2.4944 0 Td
(of)Tj
1.0148 0 Td
(both)Tj
2.0636 0 Td
(allele)Tj
2.2394 0 Td
(and)Tj
1.7291 0 Td
(genotype)Tj
3.8551 0 Td
(frequencies.)Tj
5.0116 0 Td
(The)Tj
1.7802 0 Td
(T)Tj
0.8334 0 Td
(allele)Tj
2.2393 0 Td
(of)Tj
1.0148 0 Td
(rs4663402)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 477.5244 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(ATG16L1)Tj
4.4433 0 Td
(and)Tj
1.8567 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(Indians)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01782)Tj
4.089 0 Td
(91)Tj
0 g
2.0906 0 Td
(May)Tj
2.0906 0 Td
(19,)Tj
1.5803 0 Td
(2017)Tj
35.2349 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
67 0 obj
<>stream
endstream
endobj
68 0 obj
<>stream
endstream
endobj
69 0 obj
<>stream
endstream
endobj
70 0 obj
<>stream
endstream
endobj
71 0 obj
<>stream
endstream
endobj
72 0 obj
<>stream
endstream
endobj
73 0 obj
<>stream
endstream
endobj
74 0 obj
<>stream
endstream
endobj
75 0 obj
<>stream
endstream
endobj
76 0 obj
<>stream
endstream
endobj
77 0 obj
<>stream
BT
66.402 0 Td
(11)Tj
ET
Q
endstream
endobj
78 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 80 0 R/Contents 81 0 R/TrimBox[0 0 612 792]>>
endobj
80 0 obj
[82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R 88 0 R 89 0 R 90 0 R 91 0 R 92 0 R 93 0 R 94 0 R]
endobj
82 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t001)>>
endobj
83 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t002)>>
endobj
84 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t001)>>
endobj
85 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t002)>>
endobj
86 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t002)>>
endobj
87 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t001)>>
endobj
88 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t002)>>
endobj
89 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t003)>>
endobj
90 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.g001)>>
endobj
91 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.t004)>>
endobj
92 0 obj
<>/Border[0 0 0]/Dest(Lpone.0178291.t001)>>
endobj
93 0 obj
<>/Border[0 0 0]/A 95 0 R>>
endobj
95 0 obj
<>
endobj
94 0 obj
<>/Border[0 0 0]/A 96 0 R>>
endobj
96 0 obj
<>
endobj
81 0 obj
[97 0 R 98 0 R 99 0 R 100 0 R 101 0 R 102 0 R 103 0 R 104 0 R 105 0 R]
endobj
97 0 obj
<>stream
q
0.83 0.64 0.02 0 k
308.2961 467.9433 m
337.4929 467.9433 l
h
f*
374.5134 454.9606 m
403.6535 454.9606 l
h
f*
412.7244 415.9559 m
441.8646 415.9559 l
h
f*
440.9575 402.9732 m
470.0976 402.9732 l
h
f*
519.9307 363.9685 m
549.1276 363.9685 l
h
f*
307.6724 337.9465 m
336.8693 337.9465 l
h
f*
265.4929 324.9638 m
294.6898 324.9638 l
h
f*
479.5087 255.4583 m
508.6488 255.4583 l
h
f*
220.7622 203.4142 m
240.3213 203.4142 l
h
f*
356.315 151.4268 m
385.5118 151.4268 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 495.0425 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(C)Tj
0.8844 0 Td
(allele)Tj
2.2394 0 Td
(of)Tj
1.0148 0 Td
(rs4663421)Tj
4.2803 0 Td
(were)Tj
2.1259 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(both)Tj
2.058 0 Td
(CD)Tj
1.6214 0 Td
(\(OR)Tj
1.9275 0 Td
(2.65,)Tj
2.0976 0 Td
(95%)Tj
1.9276 0 Td
(CI)Tj
1.2245 0 Td
(1.624.35)Tj
4.0422 0 Td
(and)Tj
-34.8942 -1.2982 Td
(OR)Tj
1.5873 0 Td
(3.17,)Tj
2.0977 0 Td
(95%)Tj
1.9275 0 Td
(1.915.25)Tj
4.0422 0 Td
(respectively\))Tj
5.227 0 Td
(and)Tj
1.7292 0 Td
(UC)Tj
1.6214 0 Td
(\(OR)Tj
1.9275 0 Td
(2.19,)Tj
2.0976 0 Td
(95%)Tj
1.9276 0 Td
(CI)Tj
1.2246 0 Td
(1.323.62)Tj
4.0421 0 Td
(and)Tj
1.7292 0 Td
(OR)Tj
1.5873 0 Td
(2.55,)Tj
2.0977 0 Td
(95%)Tj
-34.8659 -1.3039 Td
(CI)Tj
1.2245 0 Td
(1.524.28)Tj
4.0422 0 Td
(respectively\))Tj
5.2214 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2586 0 Td
(The)Tj
1.7858 0 Td
(genotype)Tj
3.8551 0 Td
(frequencies)Tj
4.7848 0 Td
(at)Tj
0.9524 0 Td
(rs4663402)Tj
4.2803 0 Td
(and)Tj
1.7348 0 Td
(rs4663421)Tj
-31.9235 -1.2983 Td
(were)Tj
2.1203 0 Td
(also)Tj
1.7688 0 Td
(significantly)Tj
5.091 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(IBD)Tj
1.8766 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
/F13 1 Tf
-18.6972 -1.2983 Td
(rs6737398.)Tj
/F8 1 Tf
5.3064 0 Td
(The)Tj
1.7858 0 Td
(minor)Tj
2.7326 0 Td
(G)Tj
0.9354 0 Td
(allele)Tj
2.2394 0 Td
(at)Tj
0.9524 0 Td
(this)Tj
1.6724 0 Td
(locus)Tj
2.2847 0 Td
(was)Tj
1.7008 0 Td
(protectively)Tj
4.9039 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(IBD,)Tj
2.0976 0 Td
(its)Tj
1.1452 0 Td
(fre-)Tj
-35.2117 -1.3039 Td
(quency)Tj
3.101 0 Td
(being)Tj
2.4321 0 Td
(higher)Tj
2.8063 0 Td
(in)Tj
1.0318 0 Td
(controls)Tj
3.4866 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0262 0 Td
(cases.)Tj
2.4491 0 Td
(Corresponding)Tj
6.2985 0 Td
(OR)Tj
1.5874 0 Td
(\(95%)Tj
2.2677 0 Td
(CI\))Tj
1.5647 0 Td
(values)Tj
2.6702 0 Td
(were)Tj
-34.9622 -1.2982 Td
(0.74)Tj
1.8708 0 Td
(\(0.580.94\))Tj
4.7225 0 Td
(for)Tj
1.3833 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(0.78)Tj
1.8765 0 Td
(\(0.620.99\))Tj
4.7169 0 Td
(for)Tj
1.3889 0 Td
(UC)Tj
1.6214 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.778 0 Td
(1)Tj
0 g
(\).)Tj
1.2642 0 Td
(The)Tj
1.7802 0 Td
(GG)Tj
1.6497 0 Td
(genotype)Tj
3.8608 0 Td
(at)Tj
0.9524 0 Td
(this)Tj
1.6724 0 Td
(locus)Tj
-34.8885 -1.2983 Td
(was)Tj
1.6951 0 Td
(noted)Tj
2.5284 0 Td
(in)Tj
1.0375 0 Td
(18%)Tj
1.9276 0 Td
(of)Tj
1.0148 0 Td
(HC)Tj
1.6497 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0262 0 Td
(10.4%)Tj
2.6305 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
1.6214 0 Td
(patients)Tj
3.3675 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
/F13 1 Tf
-25.3415 -1.3039 Td
(rs10210302.)Tj
/F8 1 Tf
5.8053 0 Td
(Although)Tj
4.0025 0 Td
(the)Tj
1.4683 0 Td
(minor)Tj
2.7383 0 Td
(C)Tj
0.8787 0 Td
(allele)Tj
2.2394 0 Td
(of)Tj
1.0148 0 Td
(rs10210302)Tj
4.7621 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.5703 0 Td
(reveal)Tj
2.5739 0 Td
(significant)Tj
4.388 0 Td
(associa-)Tj
-34.1799 -1.2983 Td
(tion)Tj
1.8425 0 Td
(with)Tj
1.9955 0 Td
(IBD,)Tj
2.1033 0 Td
(the)Tj
1.4684 0 Td
(CC)Tj
1.5477 0 Td
(genotype)Tj
3.8551 0 Td
(of)Tj
1.0148 0 Td
(rs10210302)Tj
4.7565 0 Td
(was)Tj
1.7007 0 Td
(protectively)Tj
4.904 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9955 0 Td
(IBD)Tj
1.8766 0 Td
(being)Tj
-33.3182 -1.2983 Td
(present)Tj
3.1634 0 Td
(in)Tj
1.0318 0 Td
(26%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(HC)Tj
1.6498 0 Td
(compared)Tj
4.2406 0 Td
(to)Tj
1.0261 0 Td
(18%)Tj
1.9276 0 Td
(of)Tj
1.0147 0 Td
(CD)Tj
1.6215 0 Td
(patients)Tj
3.3675 0 Td
(and)Tj
1.7291 0 Td
(17%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6158 0 Td
(patients)Tj
3.3675 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
/F13 1 Tf
-33.2388 -1.2982 Td
(rs2241877.)Tj
/F8 1 Tf
5.3064 0 Td
(The)Tj
1.7858 0 Td
(minor)Tj
2.7326 0 Td
(T)Tj
0.8334 0 Td
(allele)Tj
2.2393 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(rs2241877)Tj
4.2803 0 Td
(locus)Tj
2.2847 0 Td
(demonstrated)Tj
5.76 0 Td
(a)Tj
0.6576 0 Td
(protective)Tj
4.2009 0 Td
(associa-)Tj
-33.698 -1.3039 Td
(tion)Tj
1.8425 0 Td
(with)Tj
1.9955 0 Td
(UC,)Tj
1.8425 0 Td
(but)Tj
1.5534 0 Td
(not)Tj
1.5761 0 Td
(CD)Tj
1.6157 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(1)Tj
0 g
(\).)Tj
1.2643 0 Td
(Correspondingly,)Tj
7.2226 0 Td
(the)Tj
1.4683 0 Td
(TT)Tj
1.4457 0 Td
(genotype)Tj
3.8551 0 Td
(was)Tj
1.7008 0 Td
(protectively)Tj
4.9039 0 Td
(asso-)Tj
-35.07 -1.2983 Td
(ciated)Tj
2.5908 0 Td
(with)Tj
2.0012 0 Td
(UC)Tj
1.6158 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(2)Tj
0 g
(\).)Tj
-7.7952 -1.2983 Td
(The)Tj
1.7858 0 Td
(allele)Tj
2.2393 0 Td
(and)Tj
1.7292 0 Td
(genotype)Tj
3.8607 0 Td
(frequencies)Tj
4.7849 0 Td
(of)Tj
1.0148 0 Td
(rest)Tj
1.6724 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
/F9 1 Tf
1.4683 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(SNPs)Tj
2.3528 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5761 0 Td
(show)Tj
2.296 0 Td
(a)Tj
0.6576 0 Td
(significant)Tj
-33.2501 -1.3039 Td
(difference)Tj
4.2009 0 Td
(between)Tj
3.5319 0 Td
(patients)Tj
3.3676 0 Td
(and)Tj
1.7291 0 Td
(healthy)Tj
3.1351 0 Td
(individuals.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 273.5433 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Haplotype)Tj
4.663 0 Td
(analysis)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 256.5354 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Nine)Tj
2.194 0 Td
(haplotypes)Tj
4.507 0 Td
(\(A-I\))Tj
2.2734 0 Td
(were)Tj
2.126 0 Td
(constructed)Tj
4.9265 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(ten)Tj
/F9 1 Tf
1.491 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(SNPs)Tj
2.3527 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.778 0 Td
(3)Tj
0 g
(\).)Tj
1.2642 0 Td
(Despite)Tj
3.2428 0 Td
(the)Tj
-34.8942 -1.3039 Td
(existence)Tj
3.855 0 Td
(of)Tj
1.0148 0 Td
(weak)Tj
2.2564 0 Td
(LD)Tj
1.4967 0 Td
(between)Tj
3.5263 0 Td
(SNPs)Tj
2.3527 0 Td
(rs3792106)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(rs4663396)Tj
4.2803 0 Td
(\(D')Tj
1.5137 0 Td
(=)Tj
0.7994 0 Td
(0.13\),)Tj
2.4377 0 Td
(rs6737398)Tj
4.2803 0 Td
(and)Tj
-33.8227 -1.2982 Td
(rs4663396)Tj
4.2802 0 Td
(\(D')Tj
1.5137 0 Td
(=)Tj
0.7994 0 Td
(0.31\),)Tj
2.4378 0 Td
(rs6737398)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(rs3792106)Tj
4.2803 0 Td
(\(D')Tj
1.5137 0 Td
(=)Tj
0.7993 0 Td
(0.47\))Tj
2.211 0 Td
(and)Tj
1.7292 0 Td
(rs11682898)Tj
4.7621 0 Td
(&)Tj
0.9241 0 Td
(rs2241877)Tj
-31.2602 -1.2983 Td
(\(D')Tj
1.508 0 Td
(=)Tj
0.7993 0 Td
(0.64\),)Tj
2.4378 0 Td
(all)Tj
1.1509 0 Td
(the)Tj
1.4683 0 Td
(ten)Tj
1.491 0 Td
(SNPs)Tj
2.3528 0 Td
(were)Tj
2.1203 0 Td
(organized)Tj
4.1782 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(single)Tj
2.5285 0 Td
(haplotype)Tj
4.1499 0 Td
(block)Tj
2.3981 0 Td
(\(D')Tj
1.5137 0 Td
(ranging)Tj
3.3165 0 Td
(from)Tj
2.2054 0 Td
(0.76)Tj
-35.3081 -1.3039 Td
(1.0\))Tj
1.7347 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8199 0 Td
(1)Tj
0 g
(\).)Tj
1.2642 0 Td
(On)Tj
1.5137 0 Td
(assessing)Tj
3.8041 0 Td
(the)Tj
1.4683 0 Td
(differences)Tj
4.5638 0 Td
(in)Tj
1.0374 0 Td
(haplotype)Tj
4.1443 0 Td
(frequencies)Tj
4.7848 0 Td
(amidst)Tj
2.9254 0 Td
(cases)Tj
2.228 0 Td
(and)Tj
1.7291 0 Td
(controls)Tj
-33.0177 -1.2983 Td
(it)Tj
0.7823 0 Td
(was)Tj
1.7008 0 Td
(found)Tj
2.6192 0 Td
(that)Tj
1.7801 0 Td
(haplotype)Tj
4.1443 0 Td
(D)Tj
0.9581 0 Td
(was)Tj
1.6951 0 Td
(positively)Tj
4.0195 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(IBD)Tj
1.8765 0 Td
(being)Tj
2.4321 0 Td
(found)Tj
2.6192 0 Td
(in)Tj
1.0318 0 Td
(8%)Tj
1.457 0 Td
(of)Tj
1.0148 0 Td
(CD)Tj
-34.384 -1.2982 Td
(patients)Tj
3.3675 0 Td
(and)Tj
1.7291 0 Td
(6%)Tj
1.4513 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6214 0 Td
(patients)Tj
3.3676 0 Td
(compared)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(2%)Tj
1.4513 0 Td
(of)Tj
1.0148 0 Td
(controls)Tj
3.4809 0 Td
(\(P)Tj
1.1226 0 Td
(=)Tj
0.7993 0 Td
(5.8x10)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 482.8535 182.948 cm
BT
/F8 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(-6)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 491.244 178.5259 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(and)Tj
1.7291 0 Td
(0.002)Tj
2.347 0 Td
(respec-)Tj
-33.199 -1.2982 Td
(tively)Tj
2.3641 0 Td
(for)Tj
1.3833 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC\).)Tj
2.1883 0 Td
(Haplotype)Tj
4.3824 0 Td
(B)Tj
0.7993 0 Td
(exhibited)Tj
3.9288 0 Td
(a)Tj
0.652 0 Td
(protective)Tj
4.2066 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
2.0011 0 Td
(UC)Tj
1.6158 0 Td
(being)Tj
2.4321 0 Td
(present)Tj
-33.9304 -1.3039 Td
(in)Tj
1.0318 0 Td
(16%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(UC)Tj
1.6157 0 Td
(patients)Tj
3.3676 0 Td
(and)Tj
1.7348 0 Td
(22%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(HC)Tj
1.6498 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Table)Tj
2.7836 0 Td
(4)Tj
0 g
(\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Discussion)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(the)Tj
1.474 0 Td
(present)Tj
3.1634 0 Td
(study)Tj
2.3868 0 Td
(we)Tj
1.3266 0 Td
(explored)Tj
3.702 0 Td
(the)Tj
1.4683 0 Td
(association)Tj
4.6318 0 Td
(of)Tj
1.0148 0 Td
(IBD)Tj
1.8765 0 Td
(with)Tj
1.9956 0 Td
(a)Tj
0.652 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(genetic)Tj
3.0728 0 Td
(variants)Tj
3.3902 0 Td
(in)Tj
-35.6936 -1.3039 Td
(the)Tj
/F9 1 Tf
1.4683 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(gene.)Tj
2.3074 0 Td
(The)Tj
1.7801 0 Td
(SNPs)Tj
2.3527 0 Td
(rs4663421)Tj
4.2803 0 Td
(and)Tj
1.7348 0 Td
(rs4663402)Tj
4.2803 0 Td
(revealed)Tj
3.5263 0 Td
(a)Tj
0.652 0 Td
(positive)Tj
3.3165 0 Td
(association)Tj
4.6261 0 Td
(with)Tj
-34.384 -1.2982 Td
(IBD.)Tj
2.0976 0 Td
(The)Tj
1.7858 0 Td
(SNPs)Tj
2.3527 0 Td
(rs6737398)Tj
4.2803 0 Td
(and)Tj
1.7291 0 Td
(rs10210302)Tj
4.7565 0 Td
(had)Tj
1.7122 0 Td
(significant)Tj
4.388 0 Td
(protective)Tj
4.2066 0 Td
(associations,)Tj
5.21 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 703.8893 m
576 703.8893 l
576 703.3893 l
36 703.3893 l
f*
100.3037 703.3893 m
100.3037 678.3894 l
99.8036 678.3894 l
99.8036 703.3893 l
f*
99.8036 678.3894 m
36 678.3894 l
36 678.8894 l
99.8036 678.8894 l
f*
147.5033 703.3893 m
147.5033 678.3894 l
147.0033 678.3894 l
147.0033 703.3893 l
f*
147.0033 678.3894 m
100.3037 678.3894 l
100.3037 678.8894 l
147.0033 678.8894 l
f*
205.7516 703.3893 m
205.7516 678.3894 l
205.2516 678.3894 l
205.2516 703.3893 l
f*
205.2516 678.3894 m
147.5033 678.3894 l
147.5033 678.8894 l
205.2516 678.8894 l
f*
391.5366 703.3893 m
391.5366 690.8893 l
391.0365 690.8893 l
391.0365 703.3893 l
f*
391.0365 690.8893 m
205.7516 690.8893 l
205.7516 691.3894 l
391.0365 691.3894 l
f*
575.9994 690.8893 m
391.5366 690.8893 l
391.5366 691.3894 l
575.9994 691.3894 l
f*
255.4438 690.8893 m
255.4438 678.3894 l
254.9438 678.3894 l
254.9438 690.8893 l
f*
254.9438 678.3894 m
205.7516 678.3894 l
205.7516 678.8894 l
254.9438 678.8894 l
f*
310.0283 690.8893 m
310.0283 678.3894 l
309.5283 678.3894 l
309.5283 690.8893 l
f*
309.5283 678.3894 m
255.4438 678.3894 l
255.4438 678.8894 l
309.5283 678.8894 l
f*
391.5366 690.8893 m
391.5366 678.3894 l
391.0365 678.3894 l
391.0365 690.8893 l
f*
391.0365 678.3894 m
310.0283 678.3894 l
310.0283 678.8894 l
391.0365 678.8894 l
f*
441.2288 690.8893 m
441.2288 678.3894 l
440.7287 678.3894 l
440.7287 690.8893 l
f*
440.7287 678.3894 m
391.5366 678.3894 l
391.5366 678.8894 l
440.7287 678.8894 l
f*
494.9912 690.8893 m
494.9912 678.3894 l
494.4912 678.3894 l
494.4912 690.8893 l
f*
494.4912 678.3894 m
441.2288 678.3894 l
441.2288 678.8894 l
494.4912 678.8894 l
f*
575.9994 678.3894 m
494.9912 678.3894 l
494.9912 678.8894 l
575.9994 678.8894 l
f*
100.3037 678.3894 m
100.3037 665.8894 l
99.8036 665.8894 l
99.8036 678.3894 l
f*
99.8036 665.8894 m
36 665.8894 l
36 666.3895 l
99.8036 666.3895 l
f*
147.5033 678.3894 m
147.5033 665.8894 l
147.0033 665.8894 l
147.0033 678.3894 l
f*
147.0033 665.8894 m
100.3037 665.8894 l
100.3037 666.3895 l
147.0033 666.3895 l
f*
205.7516 678.3894 m
205.7516 665.8894 l
205.2516 665.8894 l
205.2516 678.3894 l
f*
205.2516 665.8894 m
147.5033 665.8894 l
147.5033 666.3895 l
205.2516 666.3895 l
f*
255.4438 678.3894 m
255.4438 665.8894 l
254.9438 665.8894 l
254.9438 678.3894 l
f*
254.9438 665.8894 m
205.7516 665.8894 l
205.7516 666.3895 l
254.9438 666.3895 l
f*
310.0283 678.3894 m
310.0283 665.8894 l
309.5283 665.8894 l
309.5283 678.3894 l
f*
309.5283 665.8894 m
255.4438 665.8894 l
255.4438 666.3895 l
309.5283 666.3895 l
f*
391.5366 678.3894 m
391.5366 665.8894 l
391.0365 665.8894 l
391.0365 678.3894 l
f*
391.0365 665.8894 m
310.0283 665.8894 l
310.0283 666.3895 l
391.0365 666.3895 l
f*
441.2288 678.3894 m
441.2288 665.8894 l
440.7287 665.8894 l
440.7287 678.3894 l
f*
440.7287 665.8894 m
391.5366 665.8894 l
391.5366 666.3895 l
440.7287 666.3895 l
f*
494.9912 678.3894 m
494.9912 665.8894 l
494.4912 665.8894 l
494.4912 678.3894 l
f*
494.4912 665.8894 m
441.2288 665.8894 l
441.2288 666.3895 l
494.4912 666.3895 l
f*
575.9994 665.8894 m
494.9912 665.8894 l
494.9912 666.3895 l
575.9994 666.3895 l
f*
100.3037 665.8894 m
100.3037 653.3895 l
99.8036 653.3895 l
99.8036 665.8894 l
f*
99.8036 653.3895 m
36 653.3895 l
36 653.8895 l
99.8036 653.8895 l
f*
147.5033 665.8894 m
147.5033 653.3895 l
147.0033 653.3895 l
147.0033 665.8894 l
f*
147.0033 653.3895 m
100.3037 653.3895 l
100.3037 653.8895 l
147.0033 653.8895 l
f*
205.7516 665.8894 m
205.7516 653.3895 l
205.2516 653.3895 l
205.2516 665.8894 l
f*
205.2516 653.3895 m
147.5033 653.3895 l
147.5033 653.8895 l
205.2516 653.8895 l
f*
255.4438 665.8894 m
255.4438 653.3895 l
254.9438 653.3895 l
254.9438 665.8894 l
f*
254.9438 653.3895 m
205.7516 653.3895 l
205.7516 653.8895 l
254.9438 653.8895 l
f*
310.0283 665.8894 m
310.0283 653.3895 l
309.5283 653.3895 l
309.5283 665.8894 l
f*
309.5283 653.3895 m
255.4438 653.3895 l
255.4438 653.8895 l
309.5283 653.8895 l
f*
391.5366 665.8894 m
391.5366 653.3895 l
391.0365 653.3895 l
391.0365 665.8894 l
f*
391.0365 653.3895 m
310.0283 653.3895 l
310.0283 653.8895 l
391.0365 653.8895 l
f*
441.2288 665.8894 m
441.2288 653.3895 l
440.7287 653.3895 l
440.7287 665.8894 l
f*
440.7287 653.3895 m
391.5366 653.3895 l
391.5366 653.8895 l
440.7287 653.8895 l
f*
494.9912 665.8894 m
494.9912 653.3895 l
494.4912 653.3895 l
494.4912 665.8894 l
f*
494.4912 653.3895 m
441.2288 653.3895 l
441.2288 653.8895 l
494.4912 653.8895 l
f*
575.9994 653.3895 m
494.9912 653.3895 l
494.9912 653.8895 l
575.9994 653.8895 l
f*
100.3037 653.3895 m
100.3037 640.8896 l
99.8036 640.8896 l
99.8036 653.3895 l
f*
99.8036 640.8896 m
36 640.8896 l
36 641.3896 l
99.8036 641.3896 l
f*
147.5033 653.3895 m
147.5033 640.8896 l
147.0033 640.8896 l
147.0033 653.3895 l
f*
147.0033 640.8896 m
100.3037 640.8896 l
100.3037 641.3896 l
147.0033 641.3896 l
f*
205.7516 653.3895 m
205.7516 640.8896 l
205.2516 640.8896 l
205.2516 653.3895 l
f*
205.2516 640.8896 m
147.5033 640.8896 l
147.5033 641.3896 l
205.2516 641.3896 l
f*
255.4438 653.3895 m
255.4438 640.8896 l
254.9438 640.8896 l
254.9438 653.3895 l
f*
254.9438 640.8896 m
205.7516 640.8896 l
205.7516 641.3896 l
254.9438 641.3896 l
f*
310.0283 653.3895 m
310.0283 640.8896 l
309.5283 640.8896 l
309.5283 653.3895 l
f*
309.5283 640.8896 m
255.4438 640.8896 l
255.4438 641.3896 l
309.5283 641.3896 l
f*
391.5366 653.3895 m
391.5366 640.8896 l
391.0365 640.8896 l
391.0365 653.3895 l
f*
391.0365 640.8896 m
310.0283 640.8896 l
310.0283 641.3896 l
391.0365 641.3896 l
f*
441.2288 653.3895 m
441.2288 640.8896 l
440.7287 640.8896 l
440.7287 653.3895 l
f*
440.7287 640.8896 m
391.5366 640.8896 l
391.5366 641.3896 l
440.7287 641.3896 l
f*
494.9912 653.3895 m
494.9912 640.8896 l
494.4912 640.8896 l
494.4912 653.3895 l
f*
494.4912 640.8896 m
441.2288 640.8896 l
441.2288 641.3896 l
494.4912 641.3896 l
f*
575.9994 640.8896 m
494.9912 640.8896 l
494.9912 641.3896 l
575.9994 641.3896 l
f*
100.3037 640.8896 m
100.3037 628.3896 l
99.8036 628.3896 l
99.8036 640.8896 l
f*
99.8036 628.3896 m
36 628.3896 l
36 628.8897 l
99.8036 628.8897 l
f*
147.5033 640.8896 m
147.5033 628.3896 l
147.0033 628.3896 l
147.0033 640.8896 l
f*
147.0033 628.3896 m
100.3037 628.3896 l
100.3037 628.8897 l
147.0033 628.8897 l
f*
205.7516 640.8896 m
205.7516 628.3896 l
205.2516 628.3896 l
205.2516 640.8896 l
f*
205.2516 628.3896 m
147.5033 628.3896 l
147.5033 628.8897 l
205.2516 628.8897 l
f*
255.4438 640.8896 m
255.4438 628.3896 l
254.9438 628.3896 l
254.9438 640.8896 l
f*
254.9438 628.3896 m
205.7516 628.3896 l
205.7516 628.8897 l
254.9438 628.8897 l
f*
310.0283 640.8896 m
310.0283 628.3896 l
309.5283 628.3896 l
309.5283 640.8896 l
f*
309.5283 628.3896 m
255.4438 628.3896 l
255.4438 628.8897 l
309.5283 628.8897 l
f*
391.5366 640.8896 m
391.5366 628.3896 l
391.0365 628.3896 l
391.0365 640.8896 l
f*
391.0365 628.3896 m
310.0283 628.3896 l
310.0283 628.8897 l
391.0365 628.8897 l
f*
441.2288 640.8896 m
441.2288 628.3896 l
440.7287 628.3896 l
440.7287 640.8896 l
f*
440.7287 628.3896 m
391.5366 628.3896 l
391.5366 628.8897 l
440.7287 628.8897 l
f*
494.9912 640.8896 m
494.9912 628.3896 l
494.4912 628.3896 l
494.4912 640.8896 l
f*
494.4912 628.3896 m
441.2288 628.3896 l
441.2288 628.8897 l
494.4912 628.8897 l
f*
575.9994 628.3896 m
494.9912 628.3896 l
494.9912 628.8897 l
575.9994 628.8897 l
f*
100.3037 628.3896 m
100.3037 615.8897 l
99.8036 615.8897 l
99.8036 628.3896 l
f*
99.8036 615.8897 m
36 615.8897 l
36 616.3897 l
99.8036 616.3897 l
f*
147.5033 628.3896 m
147.5033 615.8897 l
147.0033 615.8897 l
147.0033 628.3896 l
f*
147.0033 615.8897 m
100.3037 615.8897 l
100.3037 616.3897 l
147.0033 616.3897 l
f*
205.7516 628.3896 m
205.7516 615.8897 l
205.2516 615.8897 l
205.2516 628.3896 l
f*
205.2516 615.8897 m
147.5033 615.8897 l
147.5033 616.3897 l
205.2516 616.3897 l
f*
255.4438 628.3896 m
255.4438 615.8897 l
254.9438 615.8897 l
254.9438 628.3896 l
f*
254.9438 615.8897 m
205.7516 615.8897 l
205.7516 616.3897 l
254.9438 616.3897 l
f*
310.0283 628.3896 m
310.0283 615.8897 l
309.5283 615.8897 l
309.5283 628.3896 l
f*
309.5283 615.8897 m
255.4438 615.8897 l
255.4438 616.3897 l
309.5283 616.3897 l
f*
391.5366 628.3896 m
391.5366 615.8897 l
391.0365 615.8897 l
391.0365 628.3896 l
f*
391.0365 615.8897 m
310.0283 615.8897 l
310.0283 616.3897 l
391.0365 616.3897 l
f*
441.2288 628.3896 m
441.2288 615.8897 l
440.7287 615.8897 l
440.7287 628.3896 l
f*
440.7287 615.8897 m
391.5366 615.8897 l
391.5366 616.3897 l
440.7287 616.3897 l
f*
494.9912 628.3896 m
494.9912 615.8897 l
494.4912 615.8897 l
494.4912 628.3896 l
f*
494.4912 615.8897 m
441.2288 615.8897 l
441.2288 616.3897 l
494.4912 616.3897 l
f*
575.9994 615.8897 m
494.9912 615.8897 l
494.9912 616.3897 l
575.9994 616.3897 l
f*
100.3037 615.8897 m
100.3037 603.3898 l
99.8036 603.3898 l
99.8036 615.8897 l
f*
99.8036 603.3898 m
36 603.3898 l
36 603.8898 l
99.8036 603.8898 l
f*
147.5033 615.8897 m
147.5033 603.3898 l
147.0033 603.3898 l
147.0033 615.8897 l
f*
147.0033 603.3898 m
100.3037 603.3898 l
100.3037 603.8898 l
147.0033 603.8898 l
f*
205.7516 615.8897 m
205.7516 603.3898 l
205.2516 603.3898 l
205.2516 615.8897 l
f*
205.2516 603.3898 m
147.5033 603.3898 l
147.5033 603.8898 l
205.2516 603.8898 l
f*
255.4438 615.8897 m
255.4438 603.3898 l
254.9438 603.3898 l
254.9438 615.8897 l
f*
254.9438 603.3898 m
205.7516 603.3898 l
205.7516 603.8898 l
254.9438 603.8898 l
f*
310.0283 615.8897 m
310.0283 603.3898 l
309.5283 603.3898 l
309.5283 615.8897 l
f*
309.5283 603.3898 m
255.4438 603.3898 l
255.4438 603.8898 l
309.5283 603.8898 l
f*
391.5366 615.8897 m
391.5366 603.3898 l
391.0365 603.3898 l
391.0365 615.8897 l
f*
391.0365 603.3898 m
310.0283 603.3898 l
310.0283 603.8898 l
391.0365 603.8898 l
f*
441.2288 615.8897 m
441.2288 603.3898 l
440.7287 603.3898 l
440.7287 615.8897 l
f*
440.7287 603.3898 m
391.5366 603.3898 l
391.5366 603.8898 l
440.7287 603.8898 l
f*
494.9912 615.8897 m
494.9912 603.3898 l
494.4912 603.3898 l
494.4912 615.8897 l
f*
494.4912 603.3898 m
441.2288 603.3898 l
441.2288 603.8898 l
494.4912 603.8898 l
f*
575.9994 603.3898 m
494.9912 603.3898 l
494.9912 603.8898 l
575.9994 603.8898 l
f*
100.3037 603.3898 m
100.3037 590.8898 l
99.8036 590.8898 l
99.8036 603.3898 l
f*
99.8036 590.8898 m
36 590.8898 l
36 591.3899 l
99.8036 591.3899 l
f*
147.5033 603.3898 m
147.5033 590.8898 l
147.0033 590.8898 l
147.0033 603.3898 l
f*
147.0033 590.8898 m
100.3037 590.8898 l
100.3037 591.3899 l
147.0033 591.3899 l
f*
205.7516 603.3898 m
205.7516 590.8898 l
205.2516 590.8898 l
205.2516 603.3898 l
f*
205.2516 590.8898 m
147.5033 590.8898 l
147.5033 591.3899 l
205.2516 591.3899 l
f*
255.4438 603.3898 m
255.4438 590.8898 l
254.9438 590.8898 l
254.9438 603.3898 l
f*
254.9438 590.8898 m
205.7516 590.8898 l
205.7516 591.3899 l
254.9438 591.3899 l
f*
310.0283 603.3898 m
310.0283 590.8898 l
309.5283 590.8898 l
309.5283 603.3898 l
f*
309.5283 590.8898 m
255.4438 590.8898 l
255.4438 591.3899 l
309.5283 591.3899 l
f*
391.5366 603.3898 m
391.5366 590.8898 l
391.0365 590.8898 l
391.0365 603.3898 l
f*
391.0365 590.8898 m
310.0283 590.8898 l
310.0283 591.3899 l
391.0365 591.3899 l
f*
441.2288 603.3898 m
441.2288 590.8898 l
440.7287 590.8898 l
440.7287 603.3898 l
f*
440.7287 590.8898 m
391.5366 590.8898 l
391.5366 591.3899 l
440.7287 591.3899 l
f*
494.9912 603.3898 m
494.9912 590.8898 l
494.4912 590.8898 l
494.4912 603.3898 l
f*
494.4912 590.8898 m
441.2288 590.8898 l
441.2288 591.3899 l
494.4912 591.3899 l
f*
575.9994 590.8898 m
494.9912 590.8898 l
494.9912 591.3899 l
575.9994 591.3899 l
f*
100.3037 590.8898 m
100.3037 578.3899 l
99.8036 578.3899 l
99.8036 590.8898 l
f*
99.8036 578.3899 m
36 578.3899 l
36 578.8899 l
99.8036 578.8899 l
f*
147.5033 590.8898 m
147.5033 578.3899 l
147.0033 578.3899 l
147.0033 590.8898 l
f*
147.0033 578.3899 m
100.3037 578.3899 l
100.3037 578.8899 l
147.0033 578.8899 l
f*
205.7516 590.8898 m
205.7516 578.3899 l
205.2516 578.3899 l
205.2516 590.8898 l
f*
205.2516 578.3899 m
147.5033 578.3899 l
147.5033 578.8899 l
205.2516 578.8899 l
f*
255.4438 590.8898 m
255.4438 578.3899 l
254.9438 578.3899 l
254.9438 590.8898 l
f*
254.9438 578.3899 m
205.7516 578.3899 l
205.7516 578.8899 l
254.9438 578.8899 l
f*
310.0283 590.8898 m
310.0283 578.3899 l
309.5283 578.3899 l
309.5283 590.8898 l
f*
309.5283 578.3899 m
255.4438 578.3899 l
255.4438 578.8899 l
309.5283 578.8899 l
f*
391.5366 590.8898 m
391.5366 578.3899 l
391.0365 578.3899 l
391.0365 590.8898 l
f*
391.0365 578.3899 m
310.0283 578.3899 l
310.0283 578.8899 l
391.0365 578.8899 l
f*
441.2288 590.8898 m
441.2288 578.3899 l
440.7287 578.3899 l
440.7287 590.8898 l
f*
440.7287 578.3899 m
391.5366 578.3899 l
391.5366 578.8899 l
440.7287 578.8899 l
f*
494.9912 590.8898 m
494.9912 578.3899 l
494.4912 578.3899 l
494.4912 590.8898 l
f*
494.4912 578.3899 m
441.2288 578.3899 l
441.2288 578.8899 l
494.4912 578.8899 l
f*
575.9994 578.3899 m
494.9912 578.3899 l
494.9912 578.8899 l
575.9994 578.8899 l
f*
100.3037 578.3899 m
100.3037 565.89 l
99.8036 565.89 l
99.8036 578.3899 l
f*
99.8036 565.89 m
36 565.89 l
36 566.39 l
99.8036 566.39 l
f*
147.5033 578.3899 m
147.5033 565.89 l
147.0033 565.89 l
147.0033 578.3899 l
f*
147.0033 565.89 m
100.3037 565.89 l
100.3037 566.39 l
147.0033 566.39 l
f*
205.7516 578.3899 m
205.7516 565.89 l
205.2516 565.89 l
205.2516 578.3899 l
f*
205.2516 565.89 m
147.5033 565.89 l
147.5033 566.39 l
205.2516 566.39 l
f*
255.4438 578.3899 m
255.4438 565.89 l
254.9438 565.89 l
254.9438 578.3899 l
f*
254.9438 565.89 m
205.7516 565.89 l
205.7516 566.39 l
254.9438 566.39 l
f*
310.0283 578.3899 m
310.0283 565.89 l
309.5283 565.89 l
309.5283 578.3899 l
f*
309.5283 565.89 m
255.4438 565.89 l
255.4438 566.39 l
309.5283 566.39 l
f*
391.5366 578.3899 m
391.5366 565.89 l
391.0365 565.89 l
391.0365 578.3899 l
f*
391.0365 565.89 m
310.0283 565.89 l
310.0283 566.39 l
391.0365 566.39 l
f*
441.2288 578.3899 m
441.2288 565.89 l
440.7287 565.89 l
440.7287 578.3899 l
f*
440.7287 565.89 m
391.5366 565.89 l
391.5366 566.39 l
440.7287 566.39 l
f*
494.9912 578.3899 m
494.9912 565.89 l
494.4912 565.89 l
494.4912 578.3899 l
f*
494.4912 565.89 m
441.2288 565.89 l
441.2288 566.39 l
494.4912 566.39 l
f*
575.9994 565.89 m
494.9912 565.89 l
494.9912 566.39 l
575.9994 566.39 l
f*
100.3037 565.89 m
100.3037 553.39 l
99.8036 553.39 l
99.8036 565.89 l
f*
99.8036 553.39 m
36 553.39 l
36 553.89 l
99.8036 553.89 l
f*
147.5033 565.89 m
147.5033 553.39 l
147.0033 553.39 l
147.0033 565.89 l
f*
147.0033 553.39 m
100.3037 553.39 l
100.3037 553.89 l
147.0033 553.89 l
f*
205.7516 565.89 m
205.7516 553.39 l
205.2516 553.39 l
205.2516 565.89 l
f*
205.2516 553.39 m
147.5033 553.39 l
147.5033 553.89 l
205.2516 553.89 l
f*
255.4438 565.89 m
255.4438 553.39 l
254.9438 553.39 l
254.9438 565.89 l
f*
254.9438 553.39 m
205.7516 553.39 l
205.7516 553.89 l
254.9438 553.89 l
f*
310.0283 565.89 m
310.0283 553.39 l
309.5283 553.39 l
309.5283 565.89 l
f*
309.5283 553.39 m
255.4438 553.39 l
255.4438 553.89 l
309.5283 553.89 l
f*
391.5366 565.89 m
391.5366 553.39 l
391.0365 553.39 l
391.0365 565.89 l
f*
391.0365 553.39 m
310.0283 553.39 l
310.0283 553.89 l
391.0365 553.89 l
f*
441.2288 565.89 m
441.2288 553.39 l
440.7287 553.39 l
440.7287 565.89 l
f*
440.7287 553.39 m
391.5366 553.39 l
391.5366 553.89 l
440.7287 553.89 l
f*
494.9912 565.89 m
494.9912 553.39 l
494.4912 553.39 l
494.4912 565.89 l
f*
494.4912 553.39 m
441.2288 553.39 l
441.2288 553.89 l
494.4912 553.89 l
f*
575.9994 553.39 m
494.9912 553.39 l
494.9912 553.89 l
575.9994 553.89 l
f*
575.9994 531.6398 m
36 531.6398 l
36 532.1398 l
575.9994 532.1398 l
f*
0.83 0.64 0.02 0 k
36 518.5701 m
186.7465 518.5701 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Allele)Tj
2.8489 0 Td
(frequencies)Tj
5.7543 0 Td
(of)Tj
1.1552 0 Td
(ATG16L1)Tj
4.5567 0 Td
(SNPs)Tj
2.7921 0 Td
(in)Tj
1.1056 0 Td
(cases)Tj
2.948 0 Td
(and)Tj
1.9772 0 Td
(controls)Tj
4.1173 0 Td
(in)Tj
1.1056 0 Td
(Indian)Tj
3.1323 0 Td
(population.)Tj
0 Tc
-35.5538 -1.8567 Td
(Marker)Tj
8.2914 0 Td
(Minor)Tj
0 -1.1834 Td
(Allele)Tj
5.8961 1.1834 Td
(Controls)Tj
0 -1.1834 Td
(MAF)Tj
14.7898 1.1834 Td
(Crohn's)Tj
3.9969 0 Td
(disease)Tj
19.0632 0 Td
(Ulcerative)Tj
4.9819 0 Td
(colitis)Tj
-35.5467 -1.559 Td
(MAF)Tj
6.2079 0 Td
(P-value)Tj
6.8244 0 Td
(OR\(95%CI)Tj
4.8048 0 Td
(\))Tj
5.3859 0 Td
(MAF)Tj
6.2079 0 Td
(P-value)Tj
6.7182 0 Td
(OR\(95%CI\))Tj
/F0 1 Tf
-57.6217 -1.5662 Td
(rs102103)Tj
4.1315 0 Td
(02)Tj
4.2803 0 Td
(C)Tj
5.9032 0 Td
(0.5118)Tj
7.278 0 Td
(0.4848)Tj
6.215 0 Td
(0.359)Tj
6.8174 0 Td
(0.89\(0.711.)Tj
5.5772 0 Td
(13\))Tj
4.6135 0 Td
(0.4676)Tj
6.215 0 Td
(0.125)Tj
6.7181 0 Td
(0.83\(0.661)Tj
5.2938 0 Td
(.05\))Tj
-63.043 -1.559 Td
(rs673739)Tj
4.1315 0 Td
(8)Tj
4.2803 0 Td
(G)Tj
5.9032 0 Td
(0.4081)Tj
7.278 0 Td
(0.3398)Tj
6.215 0 Td
(0.017)Tj
6.8174 0 Td
(0.74\(0.580.)Tj
5.5772 0 Td
(94\))Tj
4.6135 0 Td
(0.3525)Tj
6.215 0 Td
(0.048)Tj
6.7181 0 Td
(0.78\(0.620)Tj
5.2938 0 Td
(.99\))Tj
-63.043 -1.5662 Td
(rs116828)Tj
4.1315 0 Td
(98)Tj
4.2803 0 Td
(T)Tj
5.9032 0 Td
(0.1671)Tj
7.278 0 Td
(0.1422)Tj
6.215 0 Td
(0.246)Tj
6.8174 0 Td
(0.82\(0.591.)Tj
5.5772 0 Td
(14\))Tj
4.6135 0 Td
(0.1701)Tj
6.215 0 Td
(0.890)Tj
6.7181 0 Td
(1.02\(0.751)Tj
5.2938 0 Td
(.38\))Tj
-63.043 -1.5591 Td
(rs224188)Tj
4.1315 0 Td
(0)Tj
4.2803 0 Td
(T)Tj
5.9032 0 Td
(0.514)Tj
7.278 0 Td
(0.5022)Tj
6.215 0 Td
(0.691)Tj
6.8174 0 Td
(0.95\(0.751.)Tj
5.5772 0 Td
(20\))Tj
4.6135 0 Td
(0.4689)Tj
6.215 0 Td
(0.125)Tj
6.7181 0 Td
(0.83\(0.661)Tj
5.2938 0 Td
(.05\))Tj
-63.043 -1.559 Td
(rs379210)Tj
4.1315 0 Td
(9)Tj
4.2803 0 Td
(C)Tj
5.9032 0 Td
(0.5039)Tj
7.278 0 Td
(0.4806)Tj
6.215 0 Td
(0.428)Tj
6.8174 0 Td
(0.91\(0.721.)Tj
5.5772 0 Td
(14\))Tj
4.6135 0 Td
(0.4694)Tj
6.215 0 Td
(0.232)Tj
6.7181 0 Td
(0.87\(0.691)Tj
5.2938 0 Td
(.09\))Tj
-63.043 -1.5662 Td
(rs224187)Tj
4.1315 0 Td
(7)Tj
4.2803 0 Td
(T)Tj
5.9032 0 Td
(0.2428)Tj
7.278 0 Td
(0.2022)Tj
6.215 0 Td
(0.100)Tj
6.8174 0 Td
(0.79\(0.591.)Tj
5.5772 0 Td
(04\))Tj
4.6135 0 Td
(0.1824)Tj
6.215 0 Td
(0.011)Tj
6.7181 0 Td
(0.69\(0.520)Tj
5.2938 0 Td
(.92\))Tj
-63.043 -1.5591 Td
(rs379210)Tj
4.1315 0 Td
(6)Tj
4.2803 0 Td
(A)Tj
5.9032 0 Td
(0.3346)Tj
7.278 0 Td
(0.337)Tj
6.215 0 Td
(0.933)Tj
6.8174 0 Td
(1.01\(0.791.)Tj
5.5772 0 Td
(29\))Tj
4.6135 0 Td
(0.3012)Tj
6.215 0 Td
(0.217)Tj
6.7181 0 Td
(0.85\(0.671)Tj
5.2938 0 Td
(.09\))Tj
-63.043 -1.5661 Td
(rs466339)Tj
4.1315 0 Td
(6)Tj
4.2803 0 Td
(T)Tj
5.9032 0 Td
(0.2742)Tj
7.278 0 Td
(0.2851)Tj
6.215 0 Td
(0.679)Tj
6.8174 0 Td
(1.05\(0.811.)Tj
5.5772 0 Td
(36\))Tj
4.6135 0 Td
(0.302)Tj
6.215 0 Td
(0.285)Tj
6.7181 0 Td
(1.14\(0.891)Tj
5.2938 0 Td
(.47\))Tj
-63.043 -1.5591 Td
(rs466340)Tj
4.1315 0 Td
(2)Tj
4.2803 0 Td
(T)Tj
5.9032 0 Td
(0.0362)Tj
7.278 0 Td
(0.0909)Tj
6.215 0 Td
(5.9x10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 282.274 572.4283 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(-5)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 313.0015 568.9133 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(2.65\(1.624.)Tj
5.5772 0 Td
(35\))Tj
4.6134 0 Td
(0.076)Tj
6.215 0 Td
(0.001)Tj
6.7182 0 Td
(2.19\(1.323)Tj
5.2937 0 Td
(.62\))Tj
-63.0429 -1.5661 Td
(rs466342)Tj
4.1315 0 Td
(1)Tj
4.2804 0 Td
(C)Tj
5.9032 0 Td
(0.0327)Tj
7.278 0 Td
(0.0968)Tj
6.215 0 Td
(2.4x10)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 282.274 559.9559 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(-6)Tj
ET
Q
q
1 j
1 J
0 w
7.9999 0 0 7.9999 313.0015 556.3842 cm
BT
/F0 1 Tf
1 TL
0 0 Td
(3.17\(1.915.)Tj
5.5772 0 Td
(25\))Tj
4.6134 0 Td
(0.079)Tj
6.215 0 Td
(0.0002)Tj
6.7182 0 Td
(2.55\(1.524)Tj
5.2937 0 Td
(.28\))Tj
-63.0429 -2.3456 Td
(MAF)Tj
2.3386 0 Td
(=)Tj
0.8079 0 Td
(minor)Tj
2.7142 0 Td
(allele)Tj
2.537 0 Td
(frequency)Tj
4.3583 0 Td
(.)Tj
0.5102 0 Td
(OR)Tj
1.7292 0 Td
(=)Tj
0.8079 0 Td
(Odds)Tj
2.6078 0 Td
(ratio.)Tj
2.445 0 Td
(CI)Tj
1.2259 0 Td
(=)Tj
0.8079 0 Td
(Condenc)Tj
4.4646 0 Td
(e)Tj
0.7866 0 Td
(interval.)Tj
0.83 0.64 0.02 0 k
/F11 1 Tf
-0.025 Tc
-28.1411 -2.2465 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4426 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0178291.t001)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 477.5244 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(ATG16L1)Tj
4.4433 0 Td
(and)Tj
1.8567 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(Indians)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01782)Tj
4.089 0 Td
(91)Tj
0 g
2.0906 0 Td
(May)Tj
2.0906 0 Td
(19,)Tj
1.5803 0 Td
(2017)Tj
35.2349 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
98 0 obj
<>stream
endstream
endobj
99 0 obj
<>stream
endstream
endobj
100 0 obj
<>stream
endstream
endobj
101 0 obj
<>stream
endstream
endobj
102 0 obj
<>stream
endstream
endobj
103 0 obj
<>stream
endstream
endobj
104 0 obj
<>stream
endstream
endobj
105 0 obj
<>stream
BT
66.402 0 Td
(11)Tj
ET
Q
endstream
endobj
106 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 107 0 R/Contents 108 0 R/TrimBox[0 0 612 792]>>
endobj
107 0 obj
[109 0 R 110 0 R 111 0 R 112 0 R 113 0 R 114 0 R 115 0 R]
endobj
109 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref006)>>
endobj
110 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref024)>>
endobj
111 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref011)>>
endobj
112 0 obj
<>/Border[0 0 0]/Dest(Rpone.0178291.ref017)>>
endobj
113 0 obj
<>/Border[0 0 0]/Dest(Lpone.0178291.t002)>>
endobj
114 0 obj
<>/Border[0 0 0]/A 116 0 R>>
endobj
116 0 obj
<>
endobj
115 0 obj
<>/Border[0 0 0]/A 117 0 R>>
endobj
117 0 obj
<>
endobj
108 0 obj
[118 0 R 119 0 R 120 0 R 121 0 R 122 0 R 123 0 R]
endobj
118 0 obj
<>stream
q
0.83 0.64 0.02 0 k
467.5465 109.1906 m
472.3087 109.1906 l
h
f*
474.5764 109.1906 m
484.1008 109.1906 l
h
f*
508.1953 96.2079 m
517.663 96.2079 l
h
f*
519.9307 96.2079 m
529.4551 96.2079 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 162.3118 cm
BT
/F8 1 Tf
1 TL
-0.004 Tc
0 0 Td
(genotype)Tj
3.855 0 Td
(level,)Tj
2.2394 0 Td
(with)Tj
2.0012 0 Td
(CD)Tj
1.6158 0 Td
(and)Tj
1.7348 0 Td
(UC.)Tj
1.8425 0 Td
(The)Tj
1.7801 0 Td
(protective)Tj
4.2066 0 Td
(association)Tj
4.6261 0 Td
(of)Tj
1.0148 0 Td
(rs2241877)Tj
4.286 0 Td
(was)Tj
1.6951 0 Td
(noted)Tj
2.5285 0 Td
(with)Tj
1.9956 0 Td
(UC)Tj
-35.4215 -1.3039 Td
(alone.)Tj
2.5965 0 Td
(While)Tj
2.6418 0 Td
(specific)Tj
3.1862 0 Td
(alleles)Tj
2.5908 0 Td
(were)Tj
2.1146 0 Td
(associated,)Tj
4.4788 0 Td
(it)Tj
0.7766 0 Td
(became)Tj
3.2429 0 Td
(clear)Tj
2.1146 0 Td
(that)Tj
1.7688 0 Td
(a)Tj
0.6463 0 Td
(single)Tj
2.5285 0 Td
(haplotype)Tj
4.1385 0 Td
(was)Tj
1.6895 0 Td
(respon-)Tj
-34.5144 -1.2982 Td
(sible)Tj
2.0239 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.474 0 Td
(strong)Tj
2.7666 0 Td
(association)Tj
4.6318 0 Td
(with)Tj
1.9955 0 Td
(both)Tj
2.058 0 Td
(CD)Tj
1.6214 0 Td
(and)Tj
1.7291 0 Td
(UC.)Tj
-18.4874 -1.2983 Td
(Following)Tj
4.2236 0 Td
(the)Tj
1.4683 0 Td
(identification)Tj
5.5842 0 Td
(of)Tj
1.0148 0 Td
(genetic)Tj
3.0727 0 Td
(alterations)Tj
4.4051 0 Td
(within)Tj
/F9 1 Tf
2.8176 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0592 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1452 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
-34.2706 -1.3039 Td
(CD)Tj
1.6157 0 Td
(and)Tj
1.7348 0 Td
(UC)Tj
1.6157 0 Td
(development)Tj
5.4142 0 Td
(by)Tj
1.1792 0 Td
(two)Tj
1.7121 0 Td
(genome)Tj
3.4072 0 Td
(wide)Tj
2.1203 0 Td
(association)Tj
4.6261 0 Td
(studies)Tj
2.9877 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(],)Tj
2.7779 0 Td
(a)Tj
0.652 0 Td
(significant)Tj
4.388 0 Td
(number)Tj
-34.2309 -1.2983 Td
(of)Tj
1.0147 0 Td
(studies)Tj
2.9877 0 Td
(have)Tj
2.058 0 Td
(replicated)Tj
4.1499 0 Td
(this)Tj
1.6781 0 Td
(association)Tj
4.6261 0 Td
(in)Tj
1.0375 0 Td
(populations)Tj
4.9492 0 Td
(of)Tj
1.0148 0 Td
(Caucasian)Tj
4.3143 0 Td
(origin)Tj
2.6476 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(],)Tj
3.2485 0 Td
(corrobo-)Tj
-33.7264 -1.2982 Td
(rating)Tj
2.6021 0 Td
(the)Tj
1.4684 0 Td
(relevance)Tj
3.9685 0 Td
(of)Tj
/F9 1 Tf
1.0148 0 Td
[()89()-5( \n)]TJ
/F8 1 Tf
4.0648 0 Td
(to)Tj
1.0261 0 Td
(IBD)Tj
1.8709 0 Td
(genesis.)Tj
3.2995 0 Td
(Earlier)Tj
2.9027 0 Td
(data)Tj
1.9105 0 Td
(suggested)Tj
4.0762 0 Td
(that)Tj
1.7745 0 Td
(all)Tj
1.1508 0 Td
(the)Tj
1.4684 0 Td
(CD)Tj
1.6214 0 Td
(risk)Tj
ET
Q
q
0.45 0.36 0.35 0.01 k
1 j
1 J
0 w
36 703.8893 m
576 703.8893 l
576 703.3893 l
36 703.3893 l
f*
116.2293 703.3893 m
116.2293 678.3894 l
115.7292 678.3894 l
115.7292 703.3893 l
f*
115.7292 678.3894 m
36 678.3894 l
36 678.8894 l
115.7292 678.8894 l
f*
194.3906 703.3893 m
194.3906 678.3894 l
193.8906 678.3894 l
193.8906 703.3893 l
f*
193.8906 678.3894 m
116.2293 678.3894 l
116.2293 678.8894 l
193.8906 678.8894 l
f*
282.782 703.3893 m
282.782 678.3894 l
282.282 678.3894 l
282.282 703.3893 l
f*
282.282 678.3894 m
194.3906 678.3894 l
194.3906 678.8894 l
282.282 678.8894 l
f*
430.5609 703.3893 m
430.5609 690.8893 l
430.0608 690.8893 l
430.0608 703.3893 l
f*
430.0608 690.8893 m
282.782 690.8893 l
282.782 691.3894 l
430.0608 691.3894 l
f*
575.9997 690.8893 m
430.5609 690.8893 l
430.5609 691.3894 l
575.9997 691.3894 l
f*
359.9592 690.8893 m
359.9592 678.3894 l
359.4591 678.3894 l
359.4591 690.8893 l
f*
359.4591 678.3894 m
282.782 678.3894 l
282.782 678.8894 l
359.4591 678.8894 l
f*
430.5609 690.8893 m
430.5609 678.3894 l
430.0608 678.3894 l
430.0608 690.8893 l
f*
430.0608 678.3894 m
359.9592 678.3894 l
359.9592 678.8894 l
430.0608 678.8894 l
f*
505.8981 690.8893 m
505.8981 678.3894 l
505.398 678.3894 l
505.398 690.8893 l
f*
505.398 678.3894 m
430.5609 678.3894 l
430.5609 678.8894 l
505.398 678.8894 l
f*
575.9997 678.3894 m
505.8981 678.3894 l
505.8981 678.8894 l
575.9997 678.8894 l
f*
116.2293 678.3894 m
116.2293 665.8894 l
115.7292 665.8894 l
115.7292 678.3894 l
f*
115.7292 665.8894 m
36 665.8894 l
36 666.3895 l
115.7292 666.3895 l
f*
194.3906 678.3894 m
194.3906 665.8894 l
193.8906 665.8894 l
193.8906 678.3894 l
f*
193.8906 665.8894 m
116.2293 665.8894 l
116.2293 666.3895 l
193.8906 666.3895 l
f*
282.782 678.3894 m
282.782 665.8894 l
282.282 665.8894 l
282.282 678.3894 l
f*
282.282 665.8894 m
194.3906 665.8894 l
194.3906 666.3895 l
282.282 666.3895 l
f*
359.9592 678.3894 m
359.9592 665.8894 l
359.4591 665.8894 l
359.4591 678.3894 l
f*
359.4591 665.8894 m
282.782 665.8894 l
282.782 666.3895 l
359.4591 666.3895 l
f*
430.5609 678.3894 m
430.5609 665.8894 l
430.0608 665.8894 l
430.0608 678.3894 l
f*
430.0608 665.8894 m
359.9592 665.8894 l
359.9592 666.3895 l
430.0608 666.3895 l
f*
505.8981 678.3894 m
505.8981 665.8894 l
505.398 665.8894 l
505.398 678.3894 l
f*
505.398 665.8894 m
430.5609 665.8894 l
430.5609 666.3895 l
505.398 666.3895 l
f*
575.9997 665.8894 m
505.8981 665.8894 l
505.8981 666.3895 l
575.9997 666.3895 l
f*
116.2293 665.8894 m
116.2293 653.3895 l
115.7292 653.3895 l
115.7292 665.8894 l
f*
115.7292 653.3895 m
36 653.3895 l
36 653.8895 l
115.7292 653.8895 l
f*
194.3906 665.8894 m
194.3906 653.3895 l
193.8906 653.3895 l
193.8906 665.8894 l
f*
193.8906 653.3895 m
116.2293 653.3895 l
116.2293 653.8895 l
193.8906 653.8895 l
f*
282.782 665.8894 m
282.782 653.3895 l
282.282 653.3895 l
282.282 665.8894 l
f*
282.282 653.3895 m
194.3906 653.3895 l
194.3906 653.8895 l
282.282 653.8895 l
f*
359.9592 665.8894 m
359.9592 653.3895 l
359.4591 653.3895 l
359.4591 665.8894 l
f*
359.4591 653.3895 m
282.782 653.3895 l
282.782 653.8895 l
359.4591 653.8895 l
f*
430.5609 665.8894 m
430.5609 653.3895 l
430.0608 653.3895 l
430.0608 665.8894 l
f*
430.0608 653.3895 m
359.9592 653.3895 l
359.9592 653.8895 l
430.0608 653.8895 l
f*
505.8981 665.8894 m
505.8981 653.3895 l
505.398 653.3895 l
505.398 665.8894 l
f*
505.398 653.3895 m
430.5609 653.3895 l
430.5609 653.8895 l
505.398 653.8895 l
f*
575.9997 653.3895 m
505.8981 653.3895 l
505.8981 653.8895 l
575.9997 653.8895 l
f*
116.2293 653.3895 m
116.2293 640.8896 l
115.7292 640.8896 l
115.7292 653.3895 l
f*
115.7292 640.8896 m
36 640.8896 l
36 641.3896 l
115.7292 641.3896 l
f*
194.3906 653.3895 m
194.3906 640.8896 l
193.8906 640.8896 l
193.8906 653.3895 l
f*
193.8906 640.8896 m
116.2293 640.8896 l
116.2293 641.3896 l
193.8906 641.3896 l
f*
282.782 653.3895 m
282.782 640.8896 l
282.282 640.8896 l
282.282 653.3895 l
f*
282.282 640.8896 m
194.3906 640.8896 l
194.3906 641.3896 l
282.282 641.3896 l
f*
359.9592 653.3895 m
359.9592 640.8896 l
359.4591 640.8896 l
359.4591 653.3895 l
f*
359.4591 640.8896 m
282.782 640.8896 l
282.782 641.3896 l
359.4591 641.3896 l
f*
430.5609 653.3895 m
430.5609 640.8896 l
430.0608 640.8896 l
430.0608 653.3895 l
f*
430.0608 640.8896 m
359.9592 640.8896 l
359.9592 641.3896 l
430.0608 641.3896 l
f*
505.8981 653.3895 m
505.8981 640.8896 l
505.398 640.8896 l
505.398 653.3895 l
f*
505.398 640.8896 m
430.5609 640.8896 l
430.5609 641.3896 l
505.398 641.3896 l
f*
575.9997 640.8896 m
505.8981 640.8896 l
505.8981 641.3896 l
575.9997 641.3896 l
f*
116.2293 640.8896 m
116.2293 618.8896 l
115.7292 618.8896 l
115.7292 640.8896 l
f*
115.7292 618.8896 m
36 618.8896 l
36 619.3896 l
115.7292 619.3896 l
f*
194.3906 640.8896 m
194.3906 618.8896 l
193.8906 618.8896 l
193.8906 640.8896 l
f*
193.8906 618.8896 m
116.2293 618.8896 l
116.2293 619.3896 l
193.8906 619.3896 l
f*
282.782 640.8896 m
282.782 618.8896 l
282.282 618.8896 l
282.282 640.8896 l
f*
282.282 618.8896 m
194.3906 618.8896 l
194.3906 619.3896 l
282.282 619.3896 l
f*
359.9592 640.8896 m
359.9592 618.8896 l
359.4591 618.8896 l
359.4591 640.8896 l
f*
359.4591 618.8896 m
282.782 618.8896 l
282.782 619.3896 l
359.4591 619.3896 l
f*
430.5609 640.8896 m
430.5609 618.8896 l
430.0608 618.8896 l
430.0608 640.8896 l
f*
430.0608 618.8896 m
359.9592 618.8896 l
359.9592 619.3896 l
430.0608 619.3896 l
f*
505.8981 640.8896 m
505.8981 618.8896 l
505.398 618.8896 l
505.398 640.8896 l
f*
505.398 618.8896 m
430.5609 618.8896 l
430.5609 619.3896 l
505.398 619.3896 l
f*
575.9997 618.8896 m
505.8981 618.8896 l
505.8981 619.3896 l
575.9997 619.3896 l
f*
116.2293 618.8896 m
116.2293 596.8896 l
115.7292 596.8896 l
115.7292 618.8896 l
f*
115.7292 596.8896 m
36 596.8896 l
36 597.3897 l
115.7292 597.3897 l
f*
194.3906 618.8896 m
194.3906 596.8896 l
193.8906 596.8896 l
193.8906 618.8896 l
f*
193.8906 596.8896 m
116.2293 596.8896 l
116.2293 597.3897 l
193.8906 597.3897 l
f*
282.782 618.8896 m
282.782 596.8896 l
282.282 596.8896 l
282.282 618.8896 l
f*
282.282 596.8896 m
194.3906 596.8896 l
194.3906 597.3897 l
282.282 597.3897 l
f*
359.9592 618.8896 m
359.9592 596.8896 l
359.4591 596.8896 l
359.4591 618.8896 l
f*
359.4591 596.8896 m
282.782 596.8896 l
282.782 597.3897 l
359.4591 597.3897 l
f*
430.5609 618.8896 m
430.5609 596.8896 l
430.0608 596.8896 l
430.0608 618.8896 l
f*
430.0608 596.8896 m
359.9592 596.8896 l
359.9592 597.3897 l
430.0608 597.3897 l
f*
505.8981 618.8896 m
505.8981 596.8896 l
505.398 596.8896 l
505.398 618.8896 l
f*
505.398 596.8896 m
430.5609 596.8896 l
430.5609 597.3897 l
505.398 597.3897 l
f*
575.9997 596.8896 m
505.8981 596.8896 l
505.8981 597.3897 l
575.9997 597.3897 l
f*
116.2293 596.8896 m
116.2293 574.8897 l
115.7292 574.8897 l
115.7292 596.8896 l
f*
115.7292 574.8897 m
36 574.8897 l
36 575.3897 l
115.7292 575.3897 l
f*
194.3906 596.8896 m
194.3906 574.8897 l
193.8906 574.8897 l
193.8906 596.8896 l
f*
193.8906 574.8897 m
116.2293 574.8897 l
116.2293 575.3897 l
193.8906 575.3897 l
f*
282.782 596.8896 m
282.782 574.8897 l
282.282 574.8897 l
282.282 596.8896 l
f*
282.282 574.8897 m
194.3906 574.8897 l
194.3906 575.3897 l
282.282 575.3897 l
f*
359.9592 596.8896 m
359.9592 574.8897 l
359.4591 574.8897 l
359.4591 596.8896 l
f*
359.4591 574.8897 m
282.782 574.8897 l
282.782 575.3897 l
359.4591 575.3897 l
f*
430.5609 596.8896 m
430.5609 574.8897 l
430.0608 574.8897 l
430.0608 596.8896 l
f*
430.0608 574.8897 m
359.9592 574.8897 l
359.9592 575.3897 l
430.0608 575.3897 l
f*
505.8981 596.8896 m
505.8981 574.8897 l
505.398 574.8897 l
505.398 596.8896 l
f*
505.398 574.8897 m
430.5609 574.8897 l
430.5609 575.3897 l
505.398 575.3897 l
f*
575.9997 574.8897 m
505.8981 574.8897 l
505.8981 575.3897 l
575.9997 575.3897 l
f*
116.2293 574.8897 m
116.2293 552.8897 l
115.7292 552.8897 l
115.7292 574.8897 l
f*
115.7292 552.8897 m
36 552.8897 l
36 553.3897 l
115.7292 553.3897 l
f*
194.3906 574.8897 m
194.3906 552.8897 l
193.8906 552.8897 l
193.8906 574.8897 l
f*
193.8906 552.8897 m
116.2293 552.8897 l
116.2293 553.3897 l
193.8906 553.3897 l
f*
282.782 574.8897 m
282.782 552.8897 l
282.282 552.8897 l
282.282 574.8897 l
f*
282.282 552.8897 m
194.3906 552.8897 l
194.3906 553.3897 l
282.282 553.3897 l
f*
359.9592 574.8897 m
359.9592 552.8897 l
359.4591 552.8897 l
359.4591 574.8897 l
f*
359.4591 552.8897 m
282.782 552.8897 l
282.782 553.3897 l
359.4591 553.3897 l
f*
430.5609 574.8897 m
430.5609 552.8897 l
430.0608 552.8897 l
430.0608 574.8897 l
f*
430.0608 552.8897 m
359.9592 552.8897 l
359.9592 553.3897 l
430.0608 553.3897 l
f*
505.8981 574.8897 m
505.8981 552.8897 l
505.398 552.8897 l
505.398 574.8897 l
f*
505.398 552.8897 m
430.5609 552.8897 l
430.5609 553.3897 l
505.398 553.3897 l
f*
575.9997 552.8897 m
505.8981 552.8897 l
505.8981 553.3897 l
575.9997 553.3897 l
f*
116.2293 552.8897 m
116.2293 540.3898 l
115.7292 540.3898 l
115.7292 552.8897 l
f*
115.7292 540.3898 m
36 540.3898 l
36 540.8898 l
115.7292 540.8898 l
f*
194.3906 552.8897 m
194.3906 540.3898 l
193.8906 540.3898 l
193.8906 552.8897 l
f*
193.8906 540.3898 m
116.2293 540.3898 l
116.2293 540.8898 l
193.8906 540.8898 l
f*
282.782 552.8897 m
282.782 540.3898 l
282.282 540.3898 l
282.282 552.8897 l
f*
282.282 540.3898 m
194.3906 540.3898 l
194.3906 540.8898 l
282.282 540.8898 l
f*
359.9592 552.8897 m
359.9592 540.3898 l
359.4591 540.3898 l
359.4591 552.8897 l
f*
359.4591 540.3898 m
282.782 540.3898 l
282.782 540.8898 l
359.4591 540.8898 l
f*
430.5609 552.8897 m
430.5609 540.3898 l
430.0608 540.3898 l
430.0608 552.8897 l
f*
430.0608 540.3898 m
359.9592 540.3898 l
359.9592 540.8898 l
430.0608 540.8898 l
f*
505.8981 552.8897 m
505.8981 540.3898 l
505.398 540.3898 l
505.398 552.8897 l
f*
505.398 540.3898 m
430.5609 540.3898 l
430.5609 540.8898 l
505.398 540.8898 l
f*
575.9997 540.3898 m
505.8981 540.3898 l
505.8981 540.8898 l
575.9997 540.8898 l
f*
116.2293 540.3898 m
116.2293 527.8898 l
115.7292 527.8898 l
115.7292 540.3898 l
f*
115.7292 527.8898 m
36 527.8898 l
36 528.3899 l
115.7292 528.3899 l
f*
194.3906 540.3898 m
194.3906 527.8898 l
193.8906 527.8898 l
193.8906 540.3898 l
f*
193.8906 527.8898 m
116.2293 527.8898 l
116.2293 528.3899 l
193.8906 528.3899 l
f*
282.782 540.3898 m
282.782 527.8898 l
282.282 527.8898 l
282.282 540.3898 l
f*
282.282 527.8898 m
194.3906 527.8898 l
194.3906 528.3899 l
282.282 528.3899 l
f*
359.9592 540.3898 m
359.9592 527.8898 l
359.4591 527.8898 l
359.4591 540.3898 l
f*
359.4591 527.8898 m
282.782 527.8898 l
282.782 528.3899 l
359.4591 528.3899 l
f*
430.5609 540.3898 m
430.5609 527.8898 l
430.0608 527.8898 l
430.0608 540.3898 l
f*
430.0608 527.8898 m
359.9592 527.8898 l
359.9592 528.3899 l
430.0608 528.3899 l
f*
505.8981 540.3898 m
505.8981 527.8898 l
505.398 527.8898 l
505.398 540.3898 l
f*
505.398 527.8898 m
430.5609 527.8898 l
430.5609 528.3899 l
505.398 528.3899 l
f*
575.9997 527.8898 m
505.8981 527.8898 l
505.8981 528.3899 l
575.9997 528.3899 l
f*
116.2293 527.8898 m
116.2293 505.8899 l
115.7292 505.8899 l
115.7292 527.8898 l
f*
115.7292 505.8899 m
36 505.8899 l
36 506.3899 l
115.7292 506.3899 l
f*
194.3906 527.8898 m
194.3906 505.8899 l
193.8906 505.8899 l
193.8906 527.8898 l
f*
193.8906 505.8899 m
116.2293 505.8899 l
116.2293 506.3899 l
193.8906 506.3899 l
f*
282.782 527.8898 m
282.782 505.8899 l
282.282 505.8899 l
282.282 527.8898 l
f*
282.282 505.8899 m
194.3906 505.8899 l
194.3906 506.3899 l
282.282 506.3899 l
f*
359.9592 527.8898 m
359.9592 505.8899 l
359.4591 505.8899 l
359.4591 527.8898 l
f*
359.4591 505.8899 m
282.782 505.8899 l
282.782 506.3899 l
359.4591 506.3899 l
f*
430.5609 527.8898 m
430.5609 505.8899 l
430.0608 505.8899 l
430.0608 527.8898 l
f*
430.0608 505.8899 m
359.9592 505.8899 l
359.9592 506.3899 l
430.0608 506.3899 l
f*
505.8981 527.8898 m
505.8981 505.8899 l
505.398 505.8899 l
505.398 527.8898 l
f*
505.398 505.8899 m
430.5609 505.8899 l
430.5609 506.3899 l
505.398 506.3899 l
f*
575.9997 505.8899 m
505.8981 505.8899 l
505.8981 506.3899 l
575.9997 506.3899 l
f*
116.2293 505.8899 m
116.2293 493.3899 l
115.7292 493.3899 l
115.7292 505.8899 l
f*
115.7292 493.3899 m
36 493.3899 l
36 493.89 l
115.7292 493.89 l
f*
194.3906 505.8899 m
194.3906 493.3899 l
193.8906 493.3899 l
193.8906 505.8899 l
f*
193.8906 493.3899 m
116.2293 493.3899 l
116.2293 493.89 l
193.8906 493.89 l
f*
282.782 505.8899 m
282.782 493.3899 l
282.282 493.3899 l
282.282 505.8899 l
f*
282.282 493.3899 m
194.3906 493.3899 l
194.3906 493.89 l
282.282 493.89 l
f*
359.9592 505.8899 m
359.9592 493.3899 l
359.4591 493.3899 l
359.4591 505.8899 l
f*
359.4591 493.3899 m
282.782 493.3899 l
282.782 493.89 l
359.4591 493.89 l
f*
430.5609 505.8899 m
430.5609 493.3899 l
430.0608 493.3899 l
430.0608 505.8899 l
f*
430.0608 493.3899 m
359.9592 493.3899 l
359.9592 493.89 l
430.0608 493.89 l
f*
505.8981 505.8899 m
505.8981 493.3899 l
505.398 493.3899 l
505.398 505.8899 l
f*
505.398 493.3899 m
430.5609 493.3899 l
430.5609 493.89 l
505.398 493.89 l
f*
575.9997 493.3899 m
505.8981 493.3899 l
505.8981 493.89 l
575.9997 493.89 l
f*
116.2293 493.3899 m
116.2293 480.89 l
115.7292 480.89 l
115.7292 493.3899 l
f*
115.7292 480.89 m
36 480.89 l
36 481.39 l
115.7292 481.39 l
f*
194.3906 493.3899 m
194.3906 480.89 l
193.8906 480.89 l
193.8906 493.3899 l
f*
193.8906 480.89 m
116.2293 480.89 l
116.2293 481.39 l
193.8906 481.39 l
f*
282.782 493.3899 m
282.782 480.89 l
282.282 480.89 l
282.282 493.3899 l
f*
282.282 480.89 m
194.3906 480.89 l
194.3906 481.39 l
282.282 481.39 l
f*
359.9592 493.3899 m
359.9592 480.89 l
359.4591 480.89 l
359.4591 493.3899 l
f*
359.4591 480.89 m
282.782 480.89 l
282.782 481.39 l
359.4591 481.39 l
f*
430.5609 493.3899 m
430.5609 480.89 l
430.0608 480.89 l
430.0608 493.3899 l
f*
430.0608 480.89 m
359.9592 480.89 l
359.9592 481.39 l
430.0608 481.39 l
f*
505.8981 493.3899 m
505.8981 480.89 l
505.398 480.89 l
505.398 493.3899 l
f*
505.398 480.89 m
430.5609 480.89 l
430.5609 481.39 l
505.398 481.39 l
f*
575.9997 480.89 m
505.8981 480.89 l
505.8981 481.39 l
575.9997 481.39 l
f*
116.2293 480.89 m
116.2293 458.89 l
115.7292 458.89 l
115.7292 480.89 l
f*
115.7292 458.89 m
36 458.89 l
36 459.39 l
115.7292 459.39 l
f*
194.3906 480.89 m
194.3906 458.89 l
193.8906 458.89 l
193.8906 480.89 l
f*
193.8906 458.89 m
116.2293 458.89 l
116.2293 459.39 l
193.8906 459.39 l
f*
282.782 480.89 m
282.782 458.89 l
282.282 458.89 l
282.282 480.89 l
f*
282.282 458.89 m
194.3906 458.89 l
194.3906 459.39 l
282.282 459.39 l
f*
359.9592 480.89 m
359.9592 458.89 l
359.4591 458.89 l
359.4591 480.89 l
f*
359.4591 458.89 m
282.782 458.89 l
282.782 459.39 l
359.4591 459.39 l
f*
430.5609 480.89 m
430.5609 458.89 l
430.0608 458.89 l
430.0608 480.89 l
f*
430.0608 458.89 m
359.9592 458.89 l
359.9592 459.39 l
430.0608 459.39 l
f*
505.8981 480.89 m
505.8981 458.89 l
505.398 458.89 l
505.398 480.89 l
f*
505.398 458.89 m
430.5609 458.89 l
430.5609 459.39 l
505.398 459.39 l
f*
575.9997 458.89 m
505.8981 458.89 l
505.8981 459.39 l
575.9997 459.39 l
f*
116.2293 458.89 m
116.2293 446.3901 l
115.7292 446.3901 l
115.7292 458.89 l
f*
115.7292 446.3901 m
36 446.3901 l
36 446.8901 l
115.7292 446.8901 l
f*
194.3906 458.89 m
194.3906 446.3901 l
193.8906 446.3901 l
193.8906 458.89 l
f*
193.8906 446.3901 m
116.2293 446.3901 l
116.2293 446.8901 l
193.8906 446.8901 l
f*
282.782 458.89 m
282.782 446.3901 l
282.282 446.3901 l
282.282 458.89 l
f*
282.282 446.3901 m
194.3906 446.3901 l
194.3906 446.8901 l
282.282 446.8901 l
f*
359.9592 458.89 m
359.9592 446.3901 l
359.4591 446.3901 l
359.4591 458.89 l
f*
359.4591 446.3901 m
282.782 446.3901 l
282.782 446.8901 l
359.4591 446.8901 l
f*
430.5609 458.89 m
430.5609 446.3901 l
430.0608 446.3901 l
430.0608 458.89 l
f*
430.0608 446.3901 m
359.9592 446.3901 l
359.9592 446.8901 l
430.0608 446.8901 l
f*
505.8981 458.89 m
505.8981 446.3901 l
505.398 446.3901 l
505.398 458.89 l
f*
505.398 446.3901 m
430.5609 446.3901 l
430.5609 446.8901 l
505.398 446.8901 l
f*
575.9997 446.3901 m
505.8981 446.3901 l
505.8981 446.8901 l
575.9997 446.8901 l
f*
116.2293 446.3901 m
116.2293 433.8901 l
115.7292 433.8901 l
115.7292 446.3901 l
f*
115.7292 433.8901 m
36 433.8901 l
36 434.3902 l
115.7292 434.3902 l
f*
194.3906 446.3901 m
194.3906 433.8901 l
193.8906 433.8901 l
193.8906 446.3901 l
f*
193.8906 433.8901 m
116.2293 433.8901 l
116.2293 434.3902 l
193.8906 434.3902 l
f*
282.782 446.3901 m
282.782 433.8901 l
282.282 433.8901 l
282.282 446.3901 l
f*
282.282 433.8901 m
194.3906 433.8901 l
194.3906 434.3902 l
282.282 434.3902 l
f*
359.9592 446.3901 m
359.9592 433.8901 l
359.4591 433.8901 l
359.4591 446.3901 l
f*
359.4591 433.8901 m
282.782 433.8901 l
282.782 434.3902 l
359.4591 434.3902 l
f*
430.5609 446.3901 m
430.5609 433.8901 l
430.0608 433.8901 l
430.0608 446.3901 l
f*
430.0608 433.8901 m
359.9592 433.8901 l
359.9592 434.3902 l
430.0608 434.3902 l
f*
505.8981 446.3901 m
505.8981 433.8901 l
505.398 433.8901 l
505.398 446.3901 l
f*
505.398 433.8901 m
430.5609 433.8901 l
430.5609 434.3902 l
505.398 434.3902 l
f*
575.9997 433.8901 m
505.8981 433.8901 l
505.8981 434.3902 l
575.9997 434.3902 l
f*
116.2293 433.8901 m
116.2293 411.8902 l
115.7292 411.8902 l
115.7292 433.8901 l
f*
115.7292 411.8902 m
36 411.8902 l
36 412.3902 l
115.7292 412.3902 l
f*
194.3906 433.8901 m
194.3906 411.8902 l
193.8906 411.8902 l
193.8906 433.8901 l
f*
193.8906 411.8902 m
116.2293 411.8902 l
116.2293 412.3902 l
193.8906 412.3902 l
f*
282.782 433.8901 m
282.782 411.8902 l
282.282 411.8902 l
282.282 433.8901 l
f*
282.282 411.8902 m
194.3906 411.8902 l
194.3906 412.3902 l
282.282 412.3902 l
f*
359.9592 433.8901 m
359.9592 411.8902 l
359.4591 411.8902 l
359.4591 433.8901 l
f*
359.4591 411.8902 m
282.782 411.8902 l
282.782 412.3902 l
359.4591 412.3902 l
f*
430.5609 433.8901 m
430.5609 411.8902 l
430.0608 411.8902 l
430.0608 433.8901 l
f*
430.0608 411.8902 m
359.9592 411.8902 l
359.9592 412.3902 l
430.0608 412.3902 l
f*
505.8981 433.8901 m
505.8981 411.8902 l
505.398 411.8902 l
505.398 433.8901 l
f*
505.398 411.8902 m
430.5609 411.8902 l
430.5609 412.3902 l
505.398 412.3902 l
f*
575.9997 411.8902 m
505.8981 411.8902 l
505.8981 412.3902 l
575.9997 412.3902 l
f*
116.2293 411.8902 m
116.2293 399.3902 l
115.7292 399.3902 l
115.7292 411.8902 l
f*
115.7292 399.3902 m
36 399.3902 l
36 399.8903 l
115.7292 399.8903 l
f*
194.3906 411.8902 m
194.3906 399.3902 l
193.8906 399.3902 l
193.8906 411.8902 l
f*
193.8906 399.3902 m
116.2293 399.3902 l
116.2293 399.8903 l
193.8906 399.8903 l
f*
282.782 411.8902 m
282.782 399.3902 l
282.282 399.3902 l
282.282 411.8902 l
f*
282.282 399.3902 m
194.3906 399.3902 l
194.3906 399.8903 l
282.282 399.8903 l
f*
359.9592 411.8902 m
359.9592 399.3902 l
359.4591 399.3902 l
359.4591 411.8902 l
f*
359.4591 399.3902 m
282.782 399.3902 l
282.782 399.8903 l
359.4591 399.8903 l
f*
430.5609 411.8902 m
430.5609 399.3902 l
430.0608 399.3902 l
430.0608 411.8902 l
f*
430.0608 399.3902 m
359.9592 399.3902 l
359.9592 399.8903 l
430.0608 399.8903 l
f*
505.8981 411.8902 m
505.8981 399.3902 l
505.398 399.3902 l
505.398 411.8902 l
f*
505.398 399.3902 m
430.5609 399.3902 l
430.5609 399.8903 l
505.398 399.8903 l
f*
575.9997 399.3902 m
505.8981 399.3902 l
505.8981 399.8903 l
575.9997 399.8903 l
f*
116.2293 399.3902 m
116.2293 386.8903 l
115.7292 386.8903 l
115.7292 399.3902 l
f*
115.7292 386.8903 m
36 386.8903 l
36 387.3903 l
115.7292 387.3903 l
f*
194.3906 399.3902 m
194.3906 386.8903 l
193.8906 386.8903 l
193.8906 399.3902 l
f*
193.8906 386.8903 m
116.2293 386.8903 l
116.2293 387.3903 l
193.8906 387.3903 l
f*
282.782 399.3902 m
282.782 386.8903 l
282.282 386.8903 l
282.282 399.3902 l
f*
282.282 386.8903 m
194.3906 386.8903 l
194.3906 387.3903 l
282.282 387.3903 l
f*
359.9592 399.3902 m
359.9592 386.8903 l
359.4591 386.8903 l
359.4591 399.3902 l
f*
359.4591 386.8903 m
282.782 386.8903 l
282.782 387.3903 l
359.4591 387.3903 l
f*
430.5609 399.3902 m
430.5609 386.8903 l
430.0608 386.8903 l
430.0608 399.3902 l
f*
430.0608 386.8903 m
359.9592 386.8903 l
359.9592 387.3903 l
430.0608 387.3903 l
f*
505.8981 399.3902 m
505.8981 386.8903 l
505.398 386.8903 l
505.398 399.3902 l
f*
505.398 386.8903 m
430.5609 386.8903 l
430.5609 387.3903 l
505.398 387.3903 l
f*
575.9997 386.8903 m
505.8981 386.8903 l
505.8981 387.3903 l
575.9997 387.3903 l
f*
116.2293 386.8903 m
116.2293 364.8903 l
115.7292 364.8903 l
115.7292 386.8903 l
f*
115.7292 364.8903 m
36 364.8903 l
36 365.3904 l
115.7292 365.3904 l
f*
194.3906 386.8903 m
194.3906 364.8903 l
193.8906 364.8903 l
193.8906 386.8903 l
f*
193.8906 364.8903 m
116.2293 364.8903 l
116.2293 365.3904 l
193.8906 365.3904 l
f*
282.782 386.8903 m
282.782 364.8903 l
282.282 364.8903 l
282.282 386.8903 l
f*
282.282 364.8903 m
194.3906 364.8903 l
194.3906 365.3904 l
282.282 365.3904 l
f*
359.9592 386.8903 m
359.9592 364.8903 l
359.4591 364.8903 l
359.4591 386.8903 l
f*
359.4591 364.8903 m
282.782 364.8903 l
282.782 365.3904 l
359.4591 365.3904 l
f*
430.5609 386.8903 m
430.5609 364.8903 l
430.0608 364.8903 l
430.0608 386.8903 l
f*
430.0608 364.8903 m
359.9592 364.8903 l
359.9592 365.3904 l
430.0608 365.3904 l
f*
505.8981 386.8903 m
505.8981 364.8903 l
505.398 364.8903 l
505.398 386.8903 l
f*
505.398 364.8903 m
430.5609 364.8903 l
430.5609 365.3904 l
505.398 365.3904 l
f*
575.9997 364.8903 m
505.8981 364.8903 l
505.8981 365.3904 l
575.9997 365.3904 l
f*
116.2293 364.8903 m
116.2293 352.3904 l
115.7292 352.3904 l
115.7292 364.8903 l
f*
115.7292 352.3904 m
36 352.3904 l
36 352.8904 l
115.7292 352.8904 l
f*
194.3906 364.8903 m
194.3906 352.3904 l
193.8906 352.3904 l
193.8906 364.8903 l
f*
193.8906 352.3904 m
116.2293 352.3904 l
116.2293 352.8904 l
193.8906 352.8904 l
f*
282.782 364.8903 m
282.782 352.3904 l
282.282 352.3904 l
282.282 364.8903 l
f*
282.282 352.3904 m
194.3906 352.3904 l
194.3906 352.8904 l
282.282 352.8904 l
f*
359.9592 364.8903 m
359.9592 352.3904 l
359.4591 352.3904 l
359.4591 364.8903 l
f*
359.4591 352.3904 m
282.782 352.3904 l
282.782 352.8904 l
359.4591 352.8904 l
f*
430.5609 364.8903 m
430.5609 352.3904 l
430.0608 352.3904 l
430.0608 364.8903 l
f*
430.0608 352.3904 m
359.9592 352.3904 l
359.9592 352.8904 l
430.0608 352.8904 l
f*
505.8981 364.8903 m
505.8981 352.3904 l
505.398 352.3904 l
505.398 364.8903 l
f*
505.398 352.3904 m
430.5609 352.3904 l
430.5609 352.8904 l
505.398 352.8904 l
f*
575.9997 352.3904 m
505.8981 352.3904 l
505.8981 352.8904 l
575.9997 352.8904 l
f*
116.2293 352.3904 m
116.2293 339.8905 l
115.7292 339.8905 l
115.7292 352.3904 l
f*
115.7292 339.8905 m
36 339.8905 l
36 340.3905 l
115.7292 340.3905 l
f*
194.3906 352.3904 m
194.3906 339.8905 l
193.8906 339.8905 l
193.8906 352.3904 l
f*
193.8906 339.8905 m
116.2293 339.8905 l
116.2293 340.3905 l
193.8906 340.3905 l
f*
282.782 352.3904 m
282.782 339.8905 l
282.282 339.8905 l
282.282 352.3904 l
f*
282.282 339.8905 m
194.3906 339.8905 l
194.3906 340.3905 l
282.282 340.3905 l
f*
359.9592 352.3904 m
359.9592 339.8905 l
359.4591 339.8905 l
359.4591 352.3904 l
f*
359.4591 339.8905 m
282.782 339.8905 l
282.782 340.3905 l
359.4591 340.3905 l
f*
430.5609 352.3904 m
430.5609 339.8905 l
430.0608 339.8905 l
430.0608 352.3904 l
f*
430.0608 339.8905 m
359.9592 339.8905 l
359.9592 340.3905 l
430.0608 340.3905 l
f*
505.8981 352.3904 m
505.8981 339.8905 l
505.398 339.8905 l
505.398 352.3904 l
f*
505.398 339.8905 m
430.5609 339.8905 l
430.5609 340.3905 l
505.398 340.3905 l
f*
575.9997 339.8905 m
505.8981 339.8905 l
505.8981 340.3905 l
575.9997 340.3905 l
f*
116.2293 339.8905 m
116.2293 317.8905 l
115.7292 317.8905 l
115.7292 339.8905 l
f*
115.7292 317.8905 m
36 317.8905 l
36 318.3905 l
115.7292 318.3905 l
f*
194.3906 339.8905 m
194.3906 317.8905 l
193.8906 317.8905 l
193.8906 339.8905 l
f*
193.8906 317.8905 m
116.2293 317.8905 l
116.2293 318.3905 l
193.8906 318.3905 l
f*
282.782 339.8905 m
282.782 317.8905 l
282.282 317.8905 l
282.282 339.8905 l
f*
282.282 317.8905 m
194.3906 317.8905 l
194.3906 318.3905 l
282.282 318.3905 l
f*
359.9592 339.8905 m
359.9592 317.8905 l
359.4591 317.8905 l
359.4591 339.8905 l
f*
359.4591 317.8905 m
282.782 317.8905 l
282.782 318.3905 l
359.4591 318.3905 l
f*
430.5609 339.8905 m
430.5609 317.8905 l
430.0608 317.8905 l
430.0608 339.8905 l
f*
430.0608 317.8905 m
359.9592 317.8905 l
359.9592 318.3905 l
430.0608 318.3905 l
f*
505.8981 339.8905 m
505.8981 317.8905 l
505.398 317.8905 l
505.398 339.8905 l
f*
505.398 317.8905 m
430.5609 317.8905 l
430.5609 318.3905 l
505.398 318.3905 l
f*
575.9997 317.8905 m
505.8981 317.8905 l
505.8981 318.3905 l
575.9997 318.3905 l
f*
116.2293 317.8905 m
116.2293 305.3906 l
115.7292 305.3906 l
115.7292 317.8905 l
f*
115.7292 305.3906 m
36 305.3906 l
36 305.8906 l
115.7292 305.8906 l
f*
194.3906 317.8905 m
194.3906 305.3906 l
193.8906 305.3906 l
193.8906 317.8905 l
f*
193.8906 305.3906 m
116.2293 305.3906 l
116.2293 305.8906 l
193.8906 305.8906 l
f*
282.782 317.8905 m
282.782 305.3906 l
282.282 305.3906 l
282.282 317.8905 l
f*
282.282 305.3906 m
194.3906 305.3906 l
194.3906 305.8906 l
282.282 305.8906 l
f*
359.9592 317.8905 m
359.9592 305.3906 l
359.4591 305.3906 l
359.4591 317.8905 l
f*
359.4591 305.3906 m
282.782 305.3906 l
282.782 305.8906 l
359.4591 305.8906 l
f*
430.5609 317.8905 m
430.5609 305.3906 l
430.0608 305.3906 l
430.0608 317.8905 l
f*
430.0608 305.3906 m
359.9592 305.3906 l
359.9592 305.8906 l
430.0608 305.8906 l
f*
505.8981 317.8905 m
505.8981 305.3906 l
505.398 305.3906 l
505.398 317.8905 l
f*
505.398 305.3906 m
430.5609 305.3906 l
430.5609 305.8906 l
505.398 305.8906 l
f*
575.9997 305.3906 m
505.8981 305.3906 l
505.8981 305.8906 l
575.9997 305.8906 l
f*
116.2293 305.3906 m
116.2293 292.8906 l
115.7292 292.8906 l
115.7292 305.3906 l
f*
115.7292 292.8906 m
36 292.8906 l
36 293.3906 l
115.7292 293.3906 l
f*
194.3906 305.3906 m
194.3906 292.8906 l
193.8906 292.8906 l
193.8906 305.3906 l
f*
193.8906 292.8906 m
116.2293 292.8906 l
116.2293 293.3906 l
193.8906 293.3906 l
f*
282.782 305.3906 m
282.782 292.8906 l
282.282 292.8906 l
282.282 305.3906 l
f*
282.282 292.8906 m
194.3906 292.8906 l
194.3906 293.3906 l
282.282 293.3906 l
f*
359.9592 305.3906 m
359.9592 292.8906 l
359.4591 292.8906 l
359.4591 305.3906 l
f*
359.4591 292.8906 m
282.782 292.8906 l
282.782 293.3906 l
359.4591 293.3906 l
f*
430.5609 305.3906 m
430.5609 292.8906 l
430.0608 292.8906 l
430.0608 305.3906 l
f*
430.0608 292.8906 m
359.9592 292.8906 l
359.9592 293.3906 l
430.0608 293.3906 l
f*
505.8981 305.3906 m
505.8981 292.8906 l
505.398 292.8906 l
505.398 305.3906 l
f*
505.398 292.8906 m
430.5609 292.8906 l
430.5609 293.3906 l
505.398 293.3906 l
f*
575.9997 292.8906 m
505.8981 292.8906 l
505.8981 293.3906 l
575.9997 293.3906 l
f*
116.2293 292.8906 m
116.2293 270.8906 l
115.7292 270.8906 l
115.7292 292.8906 l
f*
115.7292 270.8906 m
36 270.8906 l
36 271.3907 l
115.7292 271.3907 l
f*
194.3906 292.8906 m
194.3906 270.8906 l
193.8906 270.8906 l
193.8906 292.8906 l
f*
193.8906 270.8906 m
116.2293 270.8906 l
116.2293 271.3907 l
193.8906 271.3907 l
f*
282.782 292.8906 m
282.782 270.8906 l
282.282 270.8906 l
282.282 292.8906 l
f*
282.282 270.8906 m
194.3906 270.8906 l
194.3906 271.3907 l
282.282 271.3907 l
f*
359.9592 292.8906 m
359.9592 270.8906 l
359.4591 270.8906 l
359.4591 292.8906 l
f*
359.4591 270.8906 m
282.782 270.8906 l
282.782 271.3907 l
359.4591 271.3907 l
f*
430.5609 292.8906 m
430.5609 270.8906 l
430.0608 270.8906 l
430.0608 292.8906 l
f*
430.0608 270.8906 m
359.9592 270.8906 l
359.9592 271.3907 l
430.0608 271.3907 l
f*
505.8981 292.8906 m
505.8981 270.8906 l
505.398 270.8906 l
505.398 292.8906 l
f*
505.398 270.8906 m
430.5609 270.8906 l
430.5609 271.3907 l
505.398 271.3907 l
f*
575.9997 270.8906 m
505.8981 270.8906 l
505.8981 271.3907 l
575.9997 271.3907 l
f*
116.2293 270.8906 m
116.2293 258.3907 l
115.7292 258.3907 l
115.7292 270.8906 l
f*
115.7292 258.3907 m
36 258.3907 l
36 258.8907 l
115.7292 258.8907 l
f*
194.3906 270.8906 m
194.3906 258.3907 l
193.8906 258.3907 l
193.8906 270.8906 l
f*
193.8906 258.3907 m
116.2293 258.3907 l
116.2293 258.8907 l
193.8906 258.8907 l
f*
282.782 270.8906 m
282.782 258.3907 l
282.282 258.3907 l
282.282 270.8906 l
f*
282.282 258.3907 m
194.3906 258.3907 l
194.3906 258.8907 l
282.282 258.8907 l
f*
359.9592 270.8906 m
359.9592 258.3907 l
359.4591 258.3907 l
359.4591 270.8906 l
f*
359.4591 258.3907 m
282.782 258.3907 l
282.782 258.8907 l
359.4591 258.8907 l
f*
430.5609 270.8906 m
430.5609 258.3907 l
430.0608 258.3907 l
430.0608 270.8906 l
f*
430.0608 258.3907 m
359.9592 258.3907 l
359.9592 258.8907 l
430.0608 258.8907 l
f*
505.8981 270.8906 m
505.8981 258.3907 l
505.398 258.3907 l
505.398 270.8906 l
f*
505.398 258.3907 m
430.5609 258.3907 l
430.5609 258.8907 l
505.398 258.8907 l
f*
575.9997 258.3907 m
505.8981 258.3907 l
505.8981 258.8907 l
575.9997 258.8907 l
f*
116.2293 258.3907 m
116.2293 245.8908 l
115.7292 245.8908 l
115.7292 258.3907 l
f*
115.7292 245.8908 m
36 245.8908 l
36 246.3908 l
115.7292 246.3908 l
f*
194.3906 258.3907 m
194.3906 245.8908 l
193.8906 245.8908 l
193.8906 258.3907 l
f*
193.8906 245.8908 m
116.2293 245.8908 l
116.2293 246.3908 l
193.8906 246.3908 l
f*
282.782 258.3907 m
282.782 245.8908 l
282.282 245.8908 l
282.282 258.3907 l
f*
282.282 245.8908 m
194.3906 245.8908 l
194.3906 246.3908 l
282.282 246.3908 l
f*
359.9592 258.3907 m
359.9592 245.8908 l
359.4591 245.8908 l
359.4591 258.3907 l
f*
359.4591 245.8908 m
282.782 245.8908 l
282.782 246.3908 l
359.4591 246.3908 l
f*
430.5609 258.3907 m
430.5609 245.8908 l
430.0608 245.8908 l
430.0608 258.3907 l
f*
430.0608 245.8908 m
359.9592 245.8908 l
359.9592 246.3908 l
430.0608 246.3908 l
f*
505.8981 258.3907 m
505.8981 245.8908 l
505.398 245.8908 l
505.398 258.3907 l
f*
505.398 245.8908 m
430.5609 245.8908 l
430.5609 246.3908 l
505.398 246.3908 l
f*
575.9997 245.8908 m
505.8981 245.8908 l
505.8981 246.3908 l
575.9997 246.3908 l
f*
116.2293 245.8908 m
116.2293 223.8908 l
115.7292 223.8908 l
115.7292 245.8908 l
f*
115.7292 223.8908 m
36 223.8908 l
36 224.3908 l
115.7292 224.3908 l
f*
194.3906 245.8908 m
194.3906 223.8908 l
193.8906 223.8908 l
193.8906 245.8908 l
f*
193.8906 223.8908 m
116.2293 223.8908 l
116.2293 224.3908 l
193.8906 224.3908 l
f*
282.782 245.8908 m
282.782 223.8908 l
282.282 223.8908 l
282.282 245.8908 l
f*
282.282 223.8908 m
194.3906 223.8908 l
194.3906 224.3908 l
282.282 224.3908 l
f*
359.9592 245.8908 m
359.9592 223.8908 l
359.4591 223.8908 l
359.4591 245.8908 l
f*
359.4591 223.8908 m
282.782 223.8908 l
282.782 224.3908 l
359.4591 224.3908 l
f*
430.5609 245.8908 m
430.5609 223.8908 l
430.0608 223.8908 l
430.0608 245.8908 l
f*
430.0608 223.8908 m
359.9592 223.8908 l
359.9592 224.3908 l
430.0608 224.3908 l
f*
505.8981 245.8908 m
505.8981 223.8908 l
505.398 223.8908 l
505.398 245.8908 l
f*
505.398 223.8908 m
430.5609 223.8908 l
430.5609 224.3908 l
505.398 224.3908 l
f*
575.9997 223.8908 m
505.8981 223.8908 l
505.8981 224.3908 l
575.9997 224.3908 l
f*
116.2293 223.8908 m
116.2293 211.3909 l
115.7292 211.3909 l
115.7292 223.8908 l
f*
115.7292 211.3909 m
36 211.3909 l
36 211.8909 l
115.7292 211.8909 l
f*
194.3906 223.8908 m
194.3906 211.3909 l
193.8906 211.3909 l
193.8906 223.8908 l
f*
193.8906 211.3909 m
116.2293 211.3909 l
116.2293 211.8909 l
193.8906 211.8909 l
f*
282.782 223.8908 m
282.782 211.3909 l
282.282 211.3909 l
282.282 223.8908 l
f*
282.282 211.3909 m
194.3906 211.3909 l
194.3906 211.8909 l
282.282 211.8909 l
f*
359.9592 223.8908 m
359.9592 211.3909 l
359.4591 211.3909 l
359.4591 223.8908 l
f*
359.4591 211.3909 m
282.782 211.3909 l
282.782 211.8909 l
359.4591 211.8909 l
f*
430.5609 223.8908 m
430.5609 211.3909 l
430.0608 211.3909 l
430.0608 223.8908 l
f*
430.0608 211.3909 m
359.9592 211.3909 l
359.9592 211.8909 l
430.0608 211.8909 l
f*
505.8981 223.8908 m
505.8981 211.3909 l
505.398 211.3909 l
505.398 223.8908 l
f*
505.398 211.3909 m
430.5609 211.3909 l
430.5609 211.8909 l
505.398 211.8909 l
f*
575.9997 211.3909 m
505.8981 211.3909 l
505.8981 211.8909 l
575.9997 211.8909 l
f*
116.2293 211.3909 m
116.2293 198.8909 l
115.7292 198.8909 l
115.7292 211.3909 l
f*
115.7292 198.8909 m
36 198.8909 l
36 199.391 l
115.7292 199.391 l
f*
194.3906 211.3909 m
194.3906 198.8909 l
193.8906 198.8909 l
193.8906 211.3909 l
f*
193.8906 198.8909 m
116.2293 198.8909 l
116.2293 199.391 l
193.8906 199.391 l
f*
282.782 211.3909 m
282.782 198.8909 l
282.282 198.8909 l
282.282 211.3909 l
f*
282.282 198.8909 m
194.3906 198.8909 l
194.3906 199.391 l
282.282 199.391 l
f*
359.9592 211.3909 m
359.9592 198.8909 l
359.4591 198.8909 l
359.4591 211.3909 l
f*
359.4591 198.8909 m
282.782 198.8909 l
282.782 199.391 l
359.4591 199.391 l
f*
430.5609 211.3909 m
430.5609 198.8909 l
430.0608 198.8909 l
430.0608 211.3909 l
f*
430.0608 198.8909 m
359.9592 198.8909 l
359.9592 199.391 l
430.0608 199.391 l
f*
505.8981 211.3909 m
505.8981 198.8909 l
505.398 198.8909 l
505.398 211.3909 l
f*
505.398 198.8909 m
430.5609 198.8909 l
430.5609 199.391 l
505.398 199.391 l
f*
575.9997 198.8909 m
505.8981 198.8909 l
505.8981 199.391 l
575.9997 199.391 l
f*
0.83 0.64 0.02 0 k
36 185.8394 m
186.7465 185.8394 l
h
f*
0 g
7.9999 0 0 7.9999 36 708.7181 cm
BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(2.)Tj
1.2614 0 Td
(Genotype)Tj
4.7835 0 Td
(distribu)Tj
3.6213 0 Td
(tions)Tj
2.5866 0 Td
(of)Tj
1.1552 0 Td
(ATG16L1)Tj
4.5567 0 Td
(SNPs)Tj
2.7921 0 Td
(in)Tj
1.1056 0 Td
(cases)Tj
2.948 0 Td
(and)Tj
1.9772 0 Td
(controls.)Tj
0 Tc
-29.5868 -3.0401 Td
(SNP)Tj
10.2756 0 Td
(Genotype)Tj
9.7725 0 Td
(Controls)Tj
4.33 0 Td
(\(%\))Tj
11.7993 1.1834 Td
(Crohn's)Tj
4.004 0 Td
(Disease)Tj
14.2158 0 Td
(Ulcerative)Tj
4.9749 0 Td
(Colitis)Tj
-28.2758 -1.559 Td
(Patients)Tj
9.652 0 Td
(P-Value)Tj
8.8229 0 Td
(Patients)Tj
9.4182 0 Td
(P-Value)Tj
/F0 1 Tf
-58.9894 -1.5662 Td
(rs102103)Tj
4.1315 0 Td
(02)Tj
6.2717 0 Td
(TT)Tj
9.7725 0 Td
(89)Tj
1.3323 0 Td
(\(23\))Tj
9.7158 0 Td
(49)Tj
1.3323 0 Td
(\(21.3\))Tj
8.3127 0 Td
(0.04)Tj
8.83 0 Td
(59)Tj
1.3252 0 Td
(\(24\))Tj
8.0859 0 Td
(0.04)Tj
-48.7067 -1.559 Td
(TC)Tj
9.7725 0 Td
(194)Tj
1.878 0 Td
(\(51\))Tj
9.1701 0 Td
(139)Tj
1.878 0 Td
(\(60.4\))Tj
16.597 0 Td
(145)Tj
1.8779 0 Td
(\(59\))Tj
-41.1735 -1.5662 Td
(CC)Tj
9.7725 0 Td
(98)Tj
1.3323 0 Td
(\(26\))Tj
9.7158 0 Td
(42)Tj
1.3323 0 Td
(\(18.3\))Tj
17.1427 0 Td
(43\(17\))Tj
-49.6988 -1.5591 Td
(rs673739)Tj
4.1315 0 Td
(8)Tj
6.2717 0 Td
(AA)Tj
9.7725 0 Td
(137)Tj
1.878 0 Td
(\(36\))Tj
9.1701 0 Td
(98\(42.4\))Tj
9.645 0 Td
(0.03)Tj
8.83 0 Td
(100\(41\))Tj
9.4111 0 Td
(0.09)Tj
-48.7067 -2.7496 Td
(AG)Tj
9.7725 0 Td
(177)Tj
0 -1.1906 Td
(\(46\))Tj
11.0481 1.1906 Td
(109)Tj
1.878 0 Td
(\(47.2\))Tj
16.597 0 Td
(116)Tj
1.8779 0 Td
(\(48\))Tj
-41.1735 -2.7496 Td
(GG)Tj
9.7725 0 Td
(67)Tj
0 -1.1906 Td
(\(18\))Tj
11.0481 1.1906 Td
(24)Tj
1.3323 0 Td
(\(10.4\))Tj
17.1427 0 Td
(28)Tj
1.3252 0 Td
(\(11\))Tj
-51.024 -2.7497 Td
(rs116828)Tj
4.1315 0 Td
(98)Tj
6.2717 0 Td
(CC)Tj
9.7725 0 Td
(266)Tj
1.878 0 Td
(\(69\))Tj
9.1701 0 Td
(169\(73\))Tj
9.645 0 Td
(0.41)Tj
8.83 0 Td
(165\(68\))Tj
9.4111 0 Td
(0.65)Tj
-48.7067 -2.7496 Td
(CT)Tj
9.7725 0 Td
(106)Tj
1.878 0 Td
(\(28\))Tj
9.1701 0 Td
(60)Tj
1.3323 0 Td
(\(26\))Tj
17.1427 0 Td
(75)Tj
1.3252 0 Td
(\(30\))Tj
-40.6208 -1.5661 Td
(TT)Tj
9.7725 0 Td
(11)Tj
1.3323 0 Td
(\(3\))Tj
9.7158 0 Td
(3)Tj
0.7796 0 Td
(\(1\))Tj
17.6954 0 Td
(4)Tj
0.7795 0 Td
(\(2\))Tj
-50.4783 -1.5591 Td
(rs224188)Tj
4.1315 0 Td
(0)Tj
6.2717 0 Td
(CC)Tj
9.7725 0 Td
(84)Tj
1.3323 0 Td
(\(24\))Tj
9.7158 0 Td
(47\(20\))Tj
9.645 0 Td
(0.11)Tj
8.83 0 Td
(64\(27\))Tj
9.4111 0 Td
(0.22)Tj
-48.7067 -2.7496 Td
(CT)Tj
9.7725 0 Td
(178)Tj
1.878 0 Td
(\(50\))Tj
9.1701 0 Td
(135)Tj
1.878 0 Td
(\(59\))Tj
16.597 0 Td
(128)Tj
1.8779 0 Td
(\(53\))Tj
-41.1735 -1.5662 Td
(TT)Tj
9.7725 0 Td
(94)Tj
1.3323 0 Td
(\(26\))Tj
9.7158 0 Td
(48)Tj
1.3323 0 Td
(\(21\))Tj
17.1427 0 Td
(49)Tj
1.3252 0 Td
(\(20\))Tj
-51.024 -1.5591 Td
(rs379210)Tj
4.1315 0 Td
(9)Tj
6.2717 0 Td
(TT)Tj
9.7725 0 Td
(94\(25\))Tj
11.0481 0 Td
(54\(23.3\))Tj
9.645 0 Td
(0.13)Tj
8.83 0 Td
(63\(26\))Tj
9.4111 0 Td
(0.22)Tj
-48.7067 -2.7496 Td
(TC)Tj
9.7725 0 Td
(189)Tj
1.878 0 Td
(\(50\))Tj
9.1701 0 Td
(133)Tj
1.878 0 Td
(\(57.3\))Tj
16.597 0 Td
(134)Tj
1.8779 0 Td
(\(55\))Tj
-41.1735 -1.5661 Td
(CC)Tj
9.7725 0 Td
(97)Tj
1.3323 0 Td
(\(25\))Tj
9.7158 0 Td
(45)Tj
1.3323 0 Td
(\(19.4\))Tj
17.1427 0 Td
(48)Tj
1.3252 0 Td
(\(19\))Tj
-51.024 -1.5591 Td
(rs224187)Tj
4.1315 0 Td
(7)Tj
6.2717 0 Td
(CC)Tj
9.7725 0 Td
(221\(58\))Tj
11.0481 0 Td
(144\(63\))Tj
9.645 0 Td
(0.13)Tj
8.83 0 Td
(163\(67\))Tj
9.4111 0 Td
(0.04)Tj
-48.7067 -2.7496 Td
(CT)Tj
9.7725 0 Td
(135)Tj
1.878 0 Td
(\(35\))Tj
9.1701 0 Td
(79)Tj
1.3323 0 Td
(\(34\))Tj
17.1427 0 Td
(73)Tj
1.3252 0 Td
(\(30\))Tj
-40.6208 -1.5662 Td
(TT)Tj
9.7725 0 Td
(25)Tj
1.3323 0 Td
(\(7\))Tj
9.7158 0 Td
(7)Tj
0.7796 0 Td
(\(3\))Tj
17.6954 0 Td
(8)Tj
0.7795 0 Td
(\(3\))Tj
-50.4783 -1.559 Td
(rs379210)Tj
4.1315 0 Td
(6)Tj
6.2717 0 Td
(GG)Tj
9.7725 0 Td
(171\(45\))Tj
11.0481 0 Td
(95\(41\))Tj
9.645 0 Td
(0.20)Tj
8.83 0 Td
(119\(49\))Tj
9.4111 0 Td
(0.44)Tj
-48.7067 -2.7497 Td
(GA)Tj
9.7725 0 Td
(165)Tj
1.878 0 Td
(\(43\))Tj
9.1701 0 Td
(115)Tj
1.878 0 Td
(\(50\))Tj
16.597 0 Td
(103)Tj
1.8779 0 Td
(\(42\))Tj
-41.1735 -1.5661 Td
(AA)Tj
9.7725 0 Td
(45)Tj
1.3323 0 Td
(\(12\))Tj
9.7158 0 Td
(20)Tj
1.3323 0 Td
(\(9\))Tj
17.1427 0 Td
(22)Tj
1.3252 0 Td
(\(9\))Tj
-51.024 -1.5591 Td
(rs466339)Tj
4.1315 0 Td
(6)Tj
6.2717 0 Td
(CC)Tj
9.7725 0 Td
(199\(52\))Tj
11.0481 0 Td
(111)Tj
1.878 0 Td
(\(48.6\))Tj
7.767 0 Td
(0.54)Tj
8.83 0 Td
(110\(45\))Tj
9.4111 0 Td
(0.10)Tj
-48.7067 -2.7496 Td
(CT)Tj
9.7725 0 Td
(158)Tj
1.878 0 Td
(\(41\))Tj
9.1701 0 Td
(104)Tj
1.878 0 Td
(\(45.6\))Tj
16.597 0 Td
(122)Tj
1.8779 0 Td
(\(50\))Tj
-41.1735 -1.5662 Td
(TT)Tj
9.7725 0 Td
(26)Tj
1.3323 0 Td
(\(7\))Tj
9.7158 0 Td
(13)Tj
1.3323 0 Td
(\(5.7\))Tj
17.1427 0 Td
(13)Tj
1.3252 0 Td
(\(5\))Tj
-51.024 -1.559 Td
(rs466340)Tj
4.1315 0 Td
(2)Tj
6.2717 0 Td
(AA)Tj
9.7725 0 Td
(358)Tj
1.878 0 Td
(\(93\))Tj
9.1701 0 Td
(190\(82.3)Tj
3.9119 0 Td
(\))Tj
5.7331 0 Td
(0.0001)Tj
8.83 0 Td
(212\(85.)Tj
3.359 0 Td
(1\))Tj
6.0521 0 Td
(0.0029)Tj
-48.7067 -2.7497 Td
(AT)Tj
9.7725 0 Td
(28)Tj
1.3323 0 Td
(\(7\))Tj
9.7158 0 Td
(40)Tj
1.3323 0 Td
(\(17.3\))Tj
17.1427 0 Td
(36)Tj
1.3252 0 Td
(\(14.5\))Tj
-40.6208 -1.5661 Td
(TT)Tj
9.7725 0 Td
(0)Tj
11.0481 0 Td
(1)Tj
0.7796 0 Td
(\(0.4\))Tj
17.6954 0 Td
(1)Tj
0.7795 0 Td
(\(0.4\))Tj
-50.4783 -1.5591 Td
(rs466342)Tj
4.1315 0 Td
(1)Tj
6.2717 0 Td
(GG)Tj
9.7725 0 Td
(357\(93\))Tj
11.0481 0 Td
(188\(81\))Tj
9.645 0 Td
(0.0001)Tj
8.83 0 Td
(208\(85\))Tj
9.4111 0 Td
(0.0006)Tj
-48.7067 -2.7496 Td
(GC)Tj
9.7725 0 Td
(25)Tj
1.3323 0 Td
(\(7\))Tj
9.7158 0 Td
(43)Tj
1.3323 0 Td
(\(19\))Tj
17.1427 0 Td
(35)Tj
1.3252 0 Td
(\(14\))Tj
-40.6208 -1.5662 Td
(CC)Tj
9.7725 0 Td
(0)Tj
11.0481 0 Td
(1)Tj
18.475 0 Td
(2)Tj
0.7795 0 Td
(\(1\))Tj
0.83 0.64 0.02 0 k
/F11 1 Tf
-0.025 Tc
-50.4783 -1.8709 Td
(https://do)Tj
3.5575 0 Td
(i.org/10.1371/j)Tj
5.4425 0 Td
(ournal.pone)Tj
4.4079 0 Td
(.0178291.t002)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 477.5244 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(ATG16L1)Tj
4.4433 0 Td
(and)Tj
1.8567 0 Td
(IBD)Tj
1.8638 0 Td
(in)Tj
0.978 0 Td
(Indians)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01782)Tj
4.089 0 Td
(91)Tj
0 g
2.0906 0 Td
(May)Tj
2.0906 0 Td
(19,)Tj
1.5803 0 Td
(2017)Tj
35.2349 0 Td
(5)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
119 0 obj
<>stream
endstream
endobj
120 0 obj
<>stream
endstream
endobj
121 0 obj
<>stream
endstream
endobj
122 0 obj
<>stream
endstream
endobj
123 0 obj
<>stream
BT
66.402 0 Td
(11)Tj
ET
Q
endstream
endobj
124 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 127 0 R/Contents 128 0 R/TrimBox[0 0 612 792]>>
endobj
125 0 obj
<>
endobj
129 0 obj
<>
endobj
130 0 obj
<>stream
%!PS-AdobeFont-1.0
%%This font is a conversion from Helvetica-BoldOblique with the following copyright notice:
%Copyright (c) 1985, 1987, 1989, 1990 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries.
11 dict begin
/FontName /Helvetica-BoldOblique def
/FontType 1 def
/FontBBox {-166 -218 1114 770} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (Helvetica-BoldOblique) readonly def
/BaseFontName (Helvetica-BoldOblique) def
/Notice (Copyright \(c\) 1985, 1987, 1989, 1990 Adobe Systems Incorporated. All Rights Reserved.Helvetica is a trademark of Linotype AG and/or its subsidiaries.) readonly def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 32 /space put
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 48 /zero put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 57 /nine put
dup 58 /colon put
dup 59 /semicolon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 95 /underscore put
dup 96 /quoteleft put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
dup 161 /exclamdown put
dup 162 /cent put
dup 163 /sterling put
dup 164 /fraction put
dup 165 /yen put
dup 166 /florin put
dup 167 /section put
dup 168 /currency put
dup 169 /quotesingle put
dup 170 /quotedblleft put
dup 171 /guillemotleft put
dup 172 /guilsinglleft put
dup 173 /guilsinglright put
dup 174 /fi put
dup 175 /fl put
dup 177 /endash put
dup 178 /dagger put
dup 179 /daggerdbl put
dup 180 /periodcentered put
dup 182 /paragraph put
dup 183 /bullet put
dup 184 /quotesinglbase put
dup 185 /quotedblbase put
dup 186 /quotedblright put
dup 187 /guillemotright put
dup 188 /ellipsis put
dup 189 /perthousand put
dup 191 /questiondown put
dup 193 /grave put
dup 194 /acute put
dup 195 /circumflex put
dup 196 /tilde put
dup 197 /macron put
dup 198 /breve put
dup 199 /dotaccent put
dup 200 /dieresis put
dup 202 /ring put
dup 203 /cedilla put
dup 205 /hungarumlaut put
dup 206 /ogonek put
dup 207 /caron put
dup 208 /emdash put
dup 225 /AE put
dup 227 /ordfeminine put
dup 232 /Lslash put
dup 233 /Oslash put
dup 234 /OE put
dup 235 /ordmasculine put
dup 241 /ae put
dup 245 /dotlessi put
dup 248 /lslash put
dup 249 /oslash put
dup 250 /oe put
dup 251 /germandbls put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤)wRfxpc@X$UČc@:p:20eַl&^
ZXs/ 1/eP6hJ/
A&;Mg*JIWCz5*E)X3l]|44R\ΙU~d 46^g1rd͂_LSg%[JedA )AdM f?i8֦1
r=Er
PP0~y9ATcs%ak.Hl
fsVY]KEЂ0'/^{>E^2u-`r^9noT+ꜮxjpA3̕Xf~utJI͇=47~>K=ڞ_`6p6^CN>3~OA73-pqNnL o\%q^|ý㭤ro,B)/TgH#R#K/p_ӿ7EO"w
Pe4.43j̼¬`Fi(!gR;.H`:֢tL$xu5*u}NkBa^}Z$H_{HnQMj'E6