%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Joyce Yongxu Huang, Renwei Wang, Yu-Tang Gao, Jian-Min Yuan
ABO blood type and the risk of cancer – Findings from the Shanghai Cohort Study
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 13 0 R/Contents 14 0 R/TrimBox[0 0 612 792]>>
endobj
13 0 obj
[15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R]
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref001)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref001)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref005)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref010)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0184295.ref002)>>
endobj
26 0 obj
<>/Border[0 0 0]/A 27 0 R>>
endobj
27 0 obj
<>
endobj
14 0 obj
[28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R]
endobj
28 0 obj
<>stream
q
0.83 0.64 0.02 0 k
436.252 706.337 m
441.0142 706.337 l
h
f*
553.1528 680.315 m
557.915 680.315 l
h
f*
562.337 680.315 m
567.0992 680.315 l
h
f*
287.5465 654.3496 m
292.3087 654.3496 l
h
f*
551.0551 537.3354 m
555.8173 537.3354 l
h
f*
553.7197 511.3134 m
558.4819 511.3134 l
h
f*
518.9669 498.3307 m
523.7291 498.3307 l
h
f*
398.8346 459.326 m
403.5969 459.326 l
h
f*
325.5874 263.9055 m
335.0551 263.9055 l
h
f*
339.5339 263.9055 m
349.0583 263.9055 l
h
f*
335.2819 94.9039 m
340.0441 94.9039 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(gastrointestinal,)Tj
6.5763 0 Td
(bronchopulmonary,)Tj
8.2601 0 Td
(and)Tj
1.7291 0 Td
(urogenital)Tj
4.3086 0 Td
(tracts)Tj
2.4095 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(Alterations)Tj
4.6601 0 Td
(in)Tj
1.0375 0 Td
(surface)Tj
3.0501 0 Td
(glycocon-)Tj
-33.63 -1.3039 Td
(jugates)Tj
2.9876 0 Td
(may)Tj
1.9276 0 Td
(lead)Tj
1.8482 0 Td
(to)Tj
1.0261 0 Td
(modifications)Tj
5.7373 0 Td
(in)Tj
1.0375 0 Td
(intercellular)Tj
5.0456 0 Td
(adhesion,)Tj
4.0422 0 Td
(membrane)Tj
4.5637 0 Td
(signaling,)Tj
4.0479 0 Td
(and)Tj
1.7348 0 Td
(immu-)Tj
-33.9985 -1.2982 Td
(nosurveillance,)Tj
6.2248 0 Td
(which)Tj
2.6532 0 Td
(could)Tj
2.4491 0 Td
(have)Tj
2.0636 0 Td
(important)Tj
4.2803 0 Td
(implications)Tj
5.1761 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(development)Tj
5.4084 0 Td
(of)Tj
1.0148 0 Td
(cancer)Tj
2.846 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(4)Tj
0 g
(].)Tj
-35.036 -1.2983 Td
(Aird)Tj
2.0749 0 Td
(et)Tj
0.9411 0 Td
(al)Tj
0.9014 0 Td
(in)Tj
1.0318 0 Td
(1953)Tj
2.126 0 Td
(discovered)Tj
4.5071 0 Td
(a)Tj
0.6519 0 Td
(statistically)Tj
4.6091 0 Td
(significant)Tj
4.388 0 Td
(association)Tj
4.6261 0 Td
(between)Tj
3.532 0 Td
(blood)Tj
2.5115 0 Td
(type)Tj
1.9162 0 Td
(A)Tj
0.9014 0 Td
(and)Tj
-35.9147 -1.2983 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(gastric)Tj
2.8403 0 Td
(cancer)Tj
2.8459 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
1.6044 0 Td
(This)Tj
1.9843 0 Td
(finding)Tj
3.1351 0 Td
(has)Tj
1.542 0 Td
(stimulated)Tj
4.422 0 Td
(an)Tj
1.2019 0 Td
(immense)Tj
3.8834 0 Td
(amount)Tj
3.3562 0 Td
(of)Tj
1.0148 0 Td
(research)Tj
3.5547 0 Td
(that)Tj
-34.1119 -1.3039 Td
(examined)Tj
4.1272 0 Td
(the)Tj
1.4683 0 Td
(relationship)Tj
4.989 0 Td
(between)Tj
3.5319 0 Td
(ABO)Tj
2.228 0 Td
(blood)Tj
2.5172 0 Td
(type)Tj
1.9105 0 Td
(and)Tj
1.7348 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(cancer,)Tj
3.0727 0 Td
(other)Tj
2.3471 0 Td
(chronic)Tj
3.2882 0 Td
(diseases,)Tj
-33.9418 -1.2982 Td
(and)Tj
1.7291 0 Td
(infectious)Tj
4.1329 0 Td
(diseases.)Tj
3.5999 0 Td
(The)Tj
1.7859 0 Td
(results)Tj
2.8062 0 Td
(of)Tj
1.0148 0 Td
(those)Tj
2.3414 0 Td
(early)Tj
2.1487 0 Td
(studies)Tj
2.9877 0 Td
(drew)Tj
2.2223 0 Td
(severe)Tj
2.6816 0 Td
(criticisms.)Tj
4.303 0 Td
(The)Tj
1.7801 0 Td
(critiques)Tj
-33.5336 -1.2983 Td
(included)Tj
3.7133 0 Td
(\(1\))Tj
1.372 0 Td
(the)Tj
1.4683 0 Td
(use)Tj
1.5364 0 Td
(of)Tj
1.0148 0 Td
(hospital-based)Tj
5.981 0 Td
(case)Tj
1.8596 0 Td
(series)Tj
2.4264 0 Td
(that)Tj
1.7801 0 Td
(were)Tj
2.126 0 Td
(not)Tj
1.5704 0 Td
(representative)Tj
5.8393 0 Td
(for)Tj
1.3833 0 Td
(the)Tj
1.4684 0 Td
(patient)Tj
-33.5393 -1.3039 Td
(population)Tj
4.5864 0 Td
(under)Tj
2.6192 0 Td
(study,)Tj
2.6192 0 Td
(\(2\))Tj
1.3719 0 Td
(the)Tj
1.474 0 Td
(inappropriate)Tj
5.692 0 Td
(use)Tj
1.5307 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6576 0 Td
(comparison)Tj
4.9719 0 Td
(group)Tj
2.6079 0 Td
(that)Tj
1.7801 0 Td
(comprised)Tj
-30.9257 -1.2983 Td
(blood)Tj
2.5114 0 Td
(donors)Tj
3.0444 0 Td
(\(blood)Tj
2.8573 0 Td
(type)Tj
1.9106 0 Td
(O)Tj
0.9694 0 Td
(could)Tj
2.4491 0 Td
(be)Tj
1.1509 0 Td
(overrepresented)Tj
6.667 0 Td
(due)Tj
1.7008 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(universal)Tj
3.8551 0 Td
(donor)Tj
2.6815 0 Td
(status\),)Tj
3.0614 0 Td
(rela-)Tj
-35.3534 -1.2983 Td
(tives)Tj
2.0239 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(\(the)Tj
1.8085 0 Td
(similar)Tj
2.9877 0 Td
(genetic)Tj
3.0671 0 Td
(traits\))Tj
2.5908 0 Td
(or)Tj
1.0999 0 Td
(other)Tj
2.347 0 Td
(patients)Tj
3.3676 0 Td
(who)Tj
1.9388 0 Td
(were)Tj
2.126 0 Td
(admitted)Tj
3.8154 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(same)Tj
-34.0495 -1.3039 Td
(hospitals)Tj
3.736 0 Td
(for)Tj
1.389 0 Td
(other)Tj
2.347 0 Td
(diseases,)Tj
3.6057 0 Td
(and)Tj
1.7291 0 Td
(\(3\))Tj
1.3776 0 Td
(uncontrolled)Tj
5.3915 0 Td
(for)Tj
1.389 0 Td
(potential)Tj
3.7587 0 Td
(confounding)Tj
5.3801 0 Td
(effects)Tj
2.7269 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(asso-)Tj
-35.5745 -1.2982 Td
(ciation)Tj
2.965 0 Td
(between)Tj
3.5262 0 Td
(ABO)Tj
2.2337 0 Td
(blood)Tj
2.5115 0 Td
(type)Tj
1.9162 0 Td
(and)Tj
1.7291 0 Td
(disease)Tj
3.0161 0 Td
(risk.)Tj
1.9445 0 Td
(Results)Tj
3.0558 0 Td
(from)Tj
2.2053 0 Td
(well)Tj
1.8255 0 Td
(designed)Tj
3.7644 0 Td
(and)Tj
1.7291 0 Td
(well)Tj
1.8199 0 Td
(exe-)Tj
-34.2423 -1.2983 Td
(cuted)Tj
2.4207 0 Td
(prospective)Tj
4.7849 0 Td
(cohort)Tj
2.8516 0 Td
(studies)Tj
2.9877 0 Td
(would)Tj
2.7156 0 Td
(be)Tj
1.1452 0 Td
(required)Tj
3.6396 0 Td
(to)Tj
1.0262 0 Td
(confirm)Tj
3.4469 0 Td
(those)Tj
2.3357 0 Td
(early)Tj
2.1487 0 Td
(observations)Tj
5.261 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(].)Tj
1.6044 0 Td
(A)Tj
-36.3682 -1.3039 Td
(recent)Tj
2.7099 0 Td
(epidemiological)Tj
6.5593 0 Td
(study)Tj
2.3924 0 Td
(in)Tj
1.0318 0 Td
(two)Tj
1.7121 0 Td
(large)Tj
2.16 0 Td
(cohorts)Tj
3.2145 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(United)Tj
3.0217 0 Td
(States)Tj
2.5115 0 Td
(found)Tj
2.6192 0 Td
(that)Tj
1.7745 0 Td
(self-reported)Tj
-32.2127 -1.2983 Td
(ABO)Tj
2.228 0 Td
(blood)Tj
2.5171 0 Td
(types)Tj
2.2734 0 Td
(were)Tj
2.1203 0 Td
(statistically)Tj
4.6148 0 Td
(significantly)Tj
5.0853 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0148 0 Td
(pancreatic)Tj
4.3596 0 Td
(cancer)Tj
2.846 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(].)Tj
-35.0303 -1.2982 Td
(Given)Tj
2.6305 0 Td
(that)Tj
1.7745 0 Td
(ABO)Tj
2.2336 0 Td
(blood)Tj
2.5115 0 Td
(types)Tj
2.2791 0 Td
(are)Tj
1.4456 0 Td
(inherited)Tj
3.8778 0 Td
(through)Tj
3.4412 0 Td
(genes)Tj
2.4435 0 Td
(on)Tj
1.2756 0 Td
(chromosome)Tj
5.4878 0 Td
(9q34)Tj
2.1543 0 Td
([)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(],)Tj
1.5988 0 Td
(a)Tj
0.6576 0 Td
(genome-)Tj
-33.8114 -1.2983 Td
(wide)Tj
2.1203 0 Td
(association)Tj
4.6317 0 Td
(study)Tj
2.3868 0 Td
(also)Tj
1.7688 0 Td
(noted)Tj
2.5228 0 Td
(an)Tj
1.2019 0 Td
(association)Tj
4.6318 0 Td
(between)Tj
3.5263 0 Td
(DNA)Tj
2.3754 0 Td
(sequence)Tj
3.8607 0 Td
(variants)Tj
3.3903 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
/F10 1 Tf
1.474 0 Td
[()-7()]TJ
/F5 1 Tf
-34.9226 -1.3039 Td
(locus)Tj
2.2847 0 Td
(and)Tj
1.7291 0 Td
(susceptibility)Tj
5.4425 0 Td
(to)Tj
1.0204 0 Td
(pancreatic)Tj
4.3654 0 Td
(cancer.)Tj
3.067 0 Td
(These)Tj
2.5682 0 Td
(findings)Tj
3.4923 0 Td
(further)Tj
3.0273 0 Td
(support)Tj
3.3222 0 Td
(a)Tj
0.652 0 Td
(role)Tj
1.7688 0 Td
(of)Tj
1.0148 0 Td
(ABO)Tj
-33.7547 -1.2983 Td
(blood)Tj
2.5114 0 Td
(type)Tj
1.9162 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(risk)Tj
1.7178 0 Td
(marker)Tj
3.1351 0 Td
(for)Tj
1.389 0 Td
(pancreatic)Tj
4.3596 0 Td
(cancer)Tj
2.846 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(].)Tj
-18.3457 -1.2983 Td
(Epidemiologic)Tj
6.0321 0 Td
(data)Tj
1.9105 0 Td
(in)Tj
1.0375 0 Td
(Asian)Tj
2.5171 0 Td
(populations,)Tj
5.176 0 Td
(in)Tj
1.0318 0 Td
(particular)Tj
4.1103 0 Td
(from)Tj
2.211 0 Td
(population-based)Tj
7.1886 0 Td
(prospective)Tj
-32.4111 -1.3039 Td
(cohort)Tj
2.8516 0 Td
(studies,)Tj
3.2145 0 Td
(are)Tj
1.4456 0 Td
(sparse.)Tj
2.914 0 Td
(Most)Tj
2.2791 0 Td
(of)Tj
1.0147 0 Td
(previous)Tj
3.651 0 Td
(prospective)Tj
4.7849 0 Td
(studies)Tj
2.9877 0 Td
(only)Tj
1.9729 0 Td
(examined)Tj
4.1329 0 Td
(the)Tj
1.4683 0 Td
(ABO)Tj
2.228 0 Td
(blood)Tj
-34.9452 -1.2982 Td
(type)Tj
1.9105 0 Td
(with)Tj
1.9956 0 Td
(risk)Tj
1.7178 0 Td
(of)Tj
1.0147 0 Td
(single)Tj
2.5285 0 Td
(cancer)Tj
2.846 0 Td
(site.)Tj
1.7915 0 Td
(In)Tj
1.1112 0 Td
(the)Tj
1.4683 0 Td
(present)Tj
3.1634 0 Td
(study,)Tj
2.6136 0 Td
(we)Tj
1.3266 0 Td
(utilized)Tj
3.1918 0 Td
(the)Tj
1.4683 0 Td
(data)Tj
1.9105 0 Td
(set)Tj
1.304 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(prospective)Tj
-33.029 -1.2983 Td
(cohort)Tj
2.8516 0 Td
(of)Tj
1.0148 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(18,000)Tj
2.8233 0 Td
(men)Tj
2.0126 0 Td
(with)Tj
1.9955 0 Td
(up)Tj
1.2699 0 Td
(to)Tj
1.0205 0 Td
(25)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(of)Tj
1.0148 0 Td
(follow-up)Tj
4.0988 0 Td
(to)Tj
1.0205 0 Td
(examine)Tj
3.6057 0 Td
(the)Tj
1.4683 0 Td
(association)Tj
-32.0029 -1.3039 Td
(between)Tj
3.5262 0 Td
(ABO)Tj
2.2337 0 Td
(blood)Tj
2.5115 0 Td
(type)Tj
1.9162 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4684 0 Td
(risk)Tj
1.7177 0 Td
(of)Tj
1.0148 0 Td
(all)Tj
1.1452 0 Td
(cancer)Tj
2.846 0 Td
(and)Tj
1.7291 0 Td
(specific)Tj
3.1918 0 Td
(cancers)Tj
3.2031 0 Td
(by)Tj
1.1849 0 Td
(site)Tj
1.5704 0 Td
(or)Tj
1.0942 0 Td
(histology.)Tj
-32.0823 -1.2983 Td
(The)Tj
1.7801 0 Td
(determination)Tj
5.9584 0 Td
(of)Tj
1.0148 0 Td
(ABO)Tj
2.228 0 Td
(blood)Tj
2.5171 0 Td
(type)Tj
1.9106 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0295 0 Td
(study)Tj
2.3868 0 Td
(participant)Tj
4.5978 0 Td
(at)Tj
0.9524 0 Td
(baseline)Tj
3.4299 0 Td
(provided)Tj
3.8154 0 Td
(an)Tj
-34.0098 -1.2983 Td
(unique)Tj
3.0217 0 Td
(opportunity)Tj
5.0343 0 Td
(to)Tj
1.0261 0 Td
(test)Tj
1.5987 0 Td
(the)Tj
1.4684 0 Td
(hypothesis)Tj
4.4673 0 Td
(that)Tj
1.7802 0 Td
(ABO)Tj
2.228 0 Td
(blood)Tj
2.5172 0 Td
(type)Tj
1.9105 0 Td
(contributes)Tj
4.7565 0 Td
(to)Tj
1.0261 0 Td
(subsequent)Tj
4.6998 0 Td
(risk)Tj
-35.5348 -1.2982 Td
(of)Tj
1.0147 0 Td
(cancer)Tj
2.846 0 Td
(development.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 313.0015 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-6.4961 -1.5023 Td
(Study)Tj
2.7543 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 278.022 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(Shanghai)Tj
3.9004 0 Td
(Cohort)Tj
3.0955 0 Td
(Study)Tj
2.5058 0 Td
(began)Tj
2.5965 0 Td
(in)Tj
1.0375 0 Td
(1986.)Tj
2.347 0 Td
(The)Tj
1.7802 0 Td
(study)Tj
2.3924 0 Td
(design)Tj
2.812 0 Td
(and)Tj
1.7291 0 Td
(subject)Tj
3.016 0 Td
(recruitment)Tj
4.9946 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
-35.5292 -1.3039 Td
(previously)Tj
4.3483 0 Td
(described)Tj
4.0535 0 Td
(in)Tj
1.0375 0 Td
(details)Tj
2.7779 0 Td
([)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7348 0 Td
(11)Tj
0 g
(].)Tj
1.7348 0 Td
(Briefly,)Tj
3.0784 0 Td
(the)Tj
1.4683 0 Td
(cohort)Tj
2.8573 0 Td
(consisted)Tj
3.9345 0 Td
(of)Tj
1.0148 0 Td
(18,244)Tj
2.8233 0 Td
(men)Tj
2.0126 0 Td
(\(constitut-)Tj
-32.876 -1.2982 Td
(ing)Tj
1.5023 0 Td
(80%)Tj
1.9275 0 Td
(of)Tj
1.0148 0 Td
(eligible)Tj
3.0614 0 Td
(subjects\))Tj
3.7191 0 Td
(enrolled)Tj
3.5149 0 Td
(from)Tj
2.2054 0 Td
(January)Tj
3.3221 0 Td
(1,)Tj
0.9185 0 Td
(1986)Tj
2.1259 0 Td
(through)Tj
3.4413 0 Td
(September)Tj
4.4843 0 Td
(30,)Tj
1.3947 0 Td
(1989,)Tj
2.3471 0 Td
(who)Tj
-34.9793 -1.2983 Td
(were)Tj
2.1203 0 Td
(between)Tj
3.5319 0 Td
(45)Tj
1.1679 0 Td
(and)Tj
1.7291 0 Td
(64)Tj
1.1735 0 Td
(years)Tj
2.2621 0 Td
(of)Tj
1.0148 0 Td
(age)Tj
1.542 0 Td
(and)Tj
1.7348 0 Td
(resided)Tj
3.1181 0 Td
(in)Tj
1.0374 0 Td
(one)Tj
1.7008 0 Td
(of)Tj
1.0148 0 Td
(four)Tj
1.9106 0 Td
(small)Tj
2.33 0 Td
(geographically)Tj
6.0038 0 Td
(defined)Tj
-33.3919 -1.3039 Td
(communities)Tj
5.4821 0 Td
(in)Tj
1.0375 0 Td
(Shanghai,)Tj
4.1215 0 Td
(China.)Tj
2.8857 0 Td
(At)Tj
1.2019 0 Td
(enrollment,)Tj
4.8812 0 Td
(each)Tj
2.0296 0 Td
(participant)Tj
4.5978 0 Td
(was)Tj
1.6951 0 Td
(interviewed)Tj
4.9095 0 Td
(in)Tj
1.0375 0 Td
(person)Tj
-33.8794 -1.2983 Td
(by)Tj
1.1792 0 Td
(a)Tj
0.6576 0 Td
(trained)Tj
3.0897 0 Td
(research)Tj
3.5547 0 Td
(nurse)Tj
2.4491 0 Td
(using)Tj
2.3924 0 Td
(a)Tj
0.652 0 Td
(structured)Tj
4.354 0 Td
(questionnaire)Tj
5.7032 0 Td
(asking)Tj
2.7893 0 Td
(for)Tj
1.389 0 Td
(information)Tj
5.0739 0 Td
(on)Tj
1.2756 0 Td
(demo-)Tj
-34.5597 -1.2982 Td
(graphic)Tj
3.2258 0 Td
(characteristics,)Tj
6.1284 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(tobacco)Tj
3.3165 0 Td
(and)Tj
1.7291 0 Td
(alcohol)Tj
3.1125 0 Td
(use,)Tj
1.7574 0 Td
(adult)Tj
2.2564 0 Td
(dietary)Tj
2.9934 0 Td
(habits,)Tj
2.8402 0 Td
(and)Tj
1.7348 0 Td
(medical)Tj
-33.1197 -1.304 Td
(history.)Tj
3.2314 0 Td
(Following)Tj
4.218 0 Td
(the)Tj
1.4683 0 Td
(completion)Tj
4.7792 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(interview,)Tj
4.1839 0 Td
(participants)Tj
4.9606 0 Td
(were)Tj
2.1203 0 Td
(asked)Tj
2.4661 0 Td
(to)Tj
1.0262 0 Td
(provide)Tj
3.2881 0 Td
(a)Tj
0.652 0 Td
(10-mL)Tj
-34.8772 -1.2982 Td
(blood)Tj
2.5114 0 Td
(sample)Tj
3.0217 0 Td
(and)Tj
1.7348 0 Td
(a)Tj
0.652 0 Td
(single-void)Tj
4.6375 0 Td
(urine)Tj
2.3584 0 Td
(specimen.)Tj
4.2292 0 Td
(The)Tj
1.7802 0 Td
(Institutional)Tj
5.1647 0 Td
(Review)Tj
3.0954 0 Td
(Boards)Tj
2.999 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4684 0 Td
(Shang-)Tj
-34.6051 -1.2983 Td
(hai)Tj
1.4456 0 Td
(Cancer)Tj
3.0841 0 Td
(Institute)Tj
3.583 0 Td
(and)Tj
1.7347 0 Td
(the)Tj
1.4684 0 Td
(University)Tj
4.3993 0 Td
(of)Tj
1.0148 0 Td
(Pittsburgh)Tj
4.405 0 Td
(had)Tj
1.7122 0 Td
(approved)Tj
3.9684 0 Td
(the)Tj
1.4684 0 Td
(Shanghai)Tj
3.9004 0 Td
(Cohort)Tj
-32.1843 -1.2983 Td
(Study.)Tj
2.7269 0 Td
(All)Tj
1.4003 0 Td
(procedures)Tj
4.6714 0 Td
(performed)Tj
4.4674 0 Td
(were)Tj
2.126 0 Td
(in)Tj
1.0318 0 Td
(accordance)Tj
4.7395 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(ethical)Tj
2.8403 0 Td
(standards)Tj
4.0875 0 Td
(of)Tj
1.0148 0 Td
(these)Tj
2.2507 0 Td
(IRBs)Tj
-34.8205 -1.3039 Td
(and)Tj
1.7291 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(1964)Tj
2.1203 0 Td
(Helsinki)Tj
3.5943 0 Td
(declaration)Tj
4.7054 0 Td
(and)Tj
1.7292 0 Td
(its)Tj
1.1452 0 Td
(later)Tj
1.9955 0 Td
(amendments.)Tj
-19.2924 -1.2982 Td
(The)Tj
1.7858 0 Td
(ABO)Tj
2.228 0 Td
(blood)Tj
2.5171 0 Td
(type)Tj
1.9106 0 Td
(was)Tj
1.7008 0 Td
(determined)Tj
4.8528 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(baseline)Tj
3.4299 0 Td
(blood)Tj
2.5172 0 Td
(draw)Tj
2.2336 0 Td
(using)Tj
2.3925 0 Td
(a)Tj
0.6519 0 Td
(standard)Tj
-32.8816 -1.2983 Td
(test)Tj
1.5987 0 Td
(for)Tj
1.3889 0 Td
(the)Tj
1.4684 0 Td
(presence)Tj
3.7133 0 Td
(of)Tj
1.0148 0 Td
(ABO)Tj
2.2281 0 Td
(antigens)Tj
3.5659 0 Td
(in)Tj
1.0375 0 Td
(subject's)Tj
3.5943 0 Td
(whole)Tj
2.6079 0 Td
(blood)Tj
2.5114 0 Td
(at)Tj
0.9525 0 Td
(the)Tj
1.474 0 Td
(blood)Tj
2.5115 0 Td
(draw)Tj
2.2393 0 Td
(station)Tj
2.931 0 Td
(\(i.e.,)Tj
-34.8375 -1.3039 Td
(ABO)Tj
2.228 0 Td
(forward)Tj
3.4072 0 Td
(grouping)Tj
3.8891 0 Td
(method\))Tj
3.6623 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.5988 0 Td
(The)Tj
1.7858 0 Td
(test)Tj
1.5987 0 Td
(result)Tj
2.4491 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(ABO)Tj
2.2337 0 Td
(blood)Tj
2.5114 0 Td
(type)Tj
1.9162 0 Td
(was)Tj
1.7008 0 Td
(recorded)Tj
3.7928 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
-36.2945 -1.2983 Td
(study)Tj
2.3867 0 Td
(questionnaire)Tj
5.7033 0 Td
(at)Tj
0.9524 0 Td
(baseline.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 446.4566 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(ABO)Tj
2.3173 0 Td
(blood)Tj
2.6079 0 Td
(type)Tj
2.0835 0 Td
(and)Tj
1.8567 0 Td
(the)Tj
1.5874 0 Td
(risk)Tj
1.7433 0 Td
(of)Tj
1.0417 0 Td
(cancer)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01842)Tj
4.089 0 Td
(95)Tj
0 g
2.0906 0 Td
(September)Tj
5.0386 0 Td
(7,)Tj
1.0418 0 Td
(2017)Tj
32.8254 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(12)Tj
/F7 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Abbreviati)Tj
3.9118 0 Td
(ons:)Tj
/F8 1 Tf
1.8425 0 Td
(CI,)Tj
1.226 0 Td
(confidence)Tj
4.252 0 Td
(interval;)Tj
3.1252 0 Td
(HR,)Tj
1.6229 0 Td
(hazard)Tj
-15.9804 -1.3748 Td
(ratio;)Tj
2.0976 0 Td
(ICD-O,)Tj
2.7071 0 Td
(Internation)Tj
3.9969 0 Td
(al)Tj
0.8362 0 Td
(Classification)Tj
5.0812 0 Td
(of)Tj
-14.719 -1.3749 Td
(Diseases)Tj
3.5291 0 Td
(for)Tj
ET
endstream
endobj
29 0 obj
<>stream
endstream
endobj
30 0 obj
<>stream
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
BT
4.7835 81.3407 Td
(Oncology.)Tj
ET
Q
endstream
endobj
41 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 12 0 R/Annots 44 0 R/Contents 45 0 R/TrimBox[0 0 612 792]>>
endobj
42 0 obj
<>
endobj
46 0 obj
<>stream
/CIDInit/ProcSet findresource begin
12 dict begin begincmap
/CMapName/Adobe-Identity-UCS def
/CIDSystemInfo<>def
/CMapType 2 def
1 begincodespacerange
<0000>
endcodespacerange
1 beginbfchar
<0121><03C7>
endbfchar
endcmap
CMapName currentdict /CMap defineresource pop end end
endstream
endobj
47 0 obj
<>/FontDescriptor 48 0 R/DW 250/W[289[514]]>>
endobj
48 0 obj
<>
endobj
49 0 obj
<>stream
cvt f6 fpgm2Msf bglyf_ |heado 6hhea1 $hmtx&O